TARDBP protein, TAR DNA-binding protein 43 recombinant protein

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

TAR DNA-binding protein 43 recombinant protein

Catalog Number: 10-288-22134F

Buy TARDBP protein -

Size:

Related Product Names:

- TARDBP protein; TARDBP; TDP43; TDP-43; TAR DNA-binding protein 43
- TDP-43; TAR DNA binding protein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: TARDBP	Gene Name Synonym: TDP43; TDP-43
Gi #: 6678271	NCBI Acc #: NP_031401.1	Swiss Prot Acc #: Q13148
Length (aa): 414	Mol. Weight (Da): 44740	Chrom Location: 1p36.22

Linear Protein Map of Expressed Protein (sequence source from above GI#)

Fusion: T7 tag at N-terminus.

Source/Host: E Coli

Purity/Purification: 95%

Crossreactivity: human

Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.

Storage: -70 degree C. Avoid frequent freeze and thaw.

Stability: 6-12 months at -70 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for TARDBP PROTEIN:

MS, SDS: Tested

ELISA, Western Blot: Not Tested

TESTING: (secondary reagents and protocols )

SDS: Analysis of TARDBP Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. ( anti-TARDBP protein )

TARDBP protein SDS image
TARDBP

TARDBP PROTEIN TARGET DESCRIPTION:

Synonym Names for TARDBP protein: TARDBP; TDP43; TDP-43; TDP-43; TAR DNA binding protein

Function: Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3' splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis.

Subunit: Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats.

Subcellular Location: Nucleus.

Tissue Specificity: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Similarity: Contains 2 RRM (RNA recognition motif) domains.

Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

TAR DNA-binding protein 43 reacts with human.

OMIM: 605078; gene. [NCBI / EBI]

Products similar to TARDBP protein:

IgG

TARDBP (TAR DNA binding protein), IgG

TDP43, IgG

PRODUCT INTERACTIONS:

TAR DNA-binding protein 43 interacts with EXOSC10 (exosome component 10), IgG (GenWay Catalog #: 10-288-22134F).

TAR DNA-binding protein 43 interacts with PM/Scl 100 Human, Protein (GenWay Catalog #: 10-288-22134F).

SUGGESTED PROTEIN REAGENTS - GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!

BACKGROUND REFERENCES for TARDBP PROTEIN:

Background references for antibody target are not specific to GenWay products

[1] Buratti,E., Brindisi,A., Giombi,M., Tisminetzky,S., Ayala,Y.M. and Baralle,F.E.
     TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing
[2] Lehner,B. and Sanderson,C.M., et al.
     A protein interaction framework for human mRNA degradation
[3] Wang,I.F., Reddy,N.M. and Shen,C.K., et al.
     Higher order arrangement of the eukaryotic nuclear bodies
[4] Buratti,E. and Baralle,F.E., et al.
     Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9
[5] Buratti,E., Dork,T., Zuccato,E., Pagani,F., Romano,M. and Baralle,F.E.
     Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
[6] , Ou S.-H.I., Wu F., Harrich D., Garcia-Martinez L.F., Gaynor R.B.
     Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs.
[7] , Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., et al.
     Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
[8] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
[9] , Buratti E., Doerk T., Zuccato E., Pagani F., Romano M., Baralle F.E.
     Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping.
[10] , Buratti E., Baralle F.E.
     Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: TARDBP protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of TARDBP protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TARDBP protein, all related information, articles, resources about TARDBP protein are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

SERVICES AVAILABLE for TARDBP PROTEIN:

Are you interested in ELISA development for this protein?

ELISA kit and other assay development services.

Protein Expression Services for TARDBP

Function protein expression services.

For more information about the antigen please send us a question.

Having questions about IgY? Visit our IgY Resource and FAQs page.

Please inquire about antigen, protein availability or custom chicken igy antibody services.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

GenWay has a diverse line of recombinant protein expression platforms, including E. coli expression, Bacliovirus expression, yeast expression, and mammalian expression. Combining the technologies of bioinformatics, protein domain analysis, gene codon optimization, protein fusion, and protein expression in different host cells, GenWay can produce soluble and functional proteins. In particular, GenWay has the capability and vector systems for expression of difficult proteins such as proteases, kinases, glycosylated and membrane proteins. We have a very high success rate (almost 100%) and can deliver the proteins in a timely fashion. This is a core competency necessary for efficient and effective production of immunogens and affinity ligands for antibody production and purification. GenWay has over 300

recombinant proteins

offered in our catalog.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved