Alphabetical Listing of Primary Antibodies:
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0-4
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5-9
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A
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B
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C
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D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Alphabetical Listing of Proteins:
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0-4
|
5-9
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A
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B
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C
|
D
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E
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F
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G
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H
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I
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J
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K
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L
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M
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N
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O
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P
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Q
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R
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S
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T
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U
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V
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W
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X
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Y
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Z
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Peptides
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Secondary Antibodies
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ELISA Kits
Alpha-endosulfine recombinant protein
Catalog Number: 10-288-22262F
Buy ENSA protein -
Size:
1 mg ($2,500.00)
Related Product Names:
- ENSA protein; ENSA; MGC4319; MGC8394; MGC78563; Alpha-endosulfine
- ARPP-19e; Endosulfine alpha isoform 3
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
ENSA
Gene Name Synonym:
MGC4319; MGC8394; MGC78563
Gi #:
4758272
NCBI Acc #:
NP_004427.1
Swiss Prot Acc #:
O43768
Length (aa):
121
Mol. Weight (Da):
13389
Chrom Location:
1q21.2
Linear Protein Map of Expressed Protein (sequence source from above GI#)
Fusion:
His-Tag at N-terminus.
Source/Host:
E Coli
Purity/Purification:
95%
Crossreactivity:
human
Format:
10 mM Tris, pH 8.0, 0.002% NaN3, 3mM NaCl, 2.5mM Imidazole.
Storage:
-70 degree C. Avoid frequent freeze and thaw.
Stability:
6-12 months at -70 degree C.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for ENSA PROTEIN:
MS, SDS: Tested
ELISA, Western Blot: Not Tested
TESTING: (
secondary reagents
and
protocols
)
SDS:
Analysis of ENSA Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. ( anti-ENSA protein )
ENSA protein SDS image
ENSA PROTEIN TARGET DESCRIPTION:
Synonym Names for ENSA protein:
ENSA; MGC4319; MGC8394; MGC78563; ARPP-19e; Endosulfine alpha isoform 3
Function:
Endogenous ligand for sulfonylurea receptor. By inhibiting sulfonylurea from binding to the receptor, it reduces K(ATP) channel currents and thereby stimulates insulin secretion.
Subcellular Location:
Cytoplasm (By similarity).
Tissue Specificity:
Widely expressed with high levels in muscle and brain and lower levels in the pancreas.
Ptm:
Phosphorylated by PKA.
Similarity:
Belongs to the endosulfine family.
Summary:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Alpha-endosulfine reacts with human.
OMIM:
603061; gene. [
NCBI
/
EBI
]
SUGGESTED PROTEIN REAGENTS
- GenWay offers reagents to facilitate your research with cell-based assays, Mass Spectrometry, standards, calibrators, Western blot, cell culture, antibiotics, microwell substrates, and more!
BACKGROUND REFERENCES for ENSA PROTEIN:
Background references for antibody target are not specific to GenWay products
[1]
Gabrielsson,B.G., Karlsson,A.C., Lonn,M., Olofsson,L.E., Johansson,J.M., Torgerson,J.S., Sjostrom,L., Carlsson,B., Eden,S., et al.
Molecular characterization of a local sulfonylurea system in human adipose tissue
[2]
Thameem,F., Farook,V.S., Yang,X., Lee,Y.H., Permana,P.A., Bogardus,C. and Prochazka,M.
The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians
[3]
Wang,H., Craig,R.L., Schay,J., Chu,W., Das,S.K., Zhang,Z. and Elbein,S.C.
Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion
[4]
Kim,S.H. and Lubec,G., et al.
Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients
[5]
Bataille,D., et al.
Endosulfines: Novel regulators of insulin secretion
[6]
, Heron L., Virsolvy A., Peyrollier K., Gribble F.M., Le Cam A., Ashcroft F.M., Bataille D.
Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive K(ATP) channel: molecular cloning, expression and biological properties.
[7]
, Heron L., Virsolvy A., Apiou F., Le Cam A., Bataille D.
Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels.
[8]
, Zhang Q., Fu G., Wu J., Zhou J., Ye M., Shen Y., Kan L., He K., Gu B., Chen S., et al.
Human alpha endosulfine gene.
[9]
, Scott V.E.S., Roch J.-M., Davis-Taber R.A., Molinari E.J., Whiteaker K.L., Gopalakrishnan M., Idler K., Sullivan J.P.
Cloning and molecular characterization of two isoforms of human endosulfine.
[10]
, Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
ENSA protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of ENSA protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ENSA protein, all related information, articles, resources about ENSA protein are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
SERVICES AVAILABLE for ENSA PROTEIN:
Are you interested in
ELISA development
for this protein?
ELISA kit
and other
assay development services
.
Protein Expression Services
for ENSA
Function protein expression services
.
For more information about the antigen please
send us a question
.
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page.
Please
inquire
about antigen, protein availability or custom chicken igy antibody services.
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
GenWay has a diverse line of recombinant protein expression platforms, including E. coli expression, Bacliovirus expression, yeast expression, and mammalian expression. Combining the technologies of bioinformatics, protein domain analysis, gene codon optimization, protein fusion, and protein expression in different host cells, GenWay can produce soluble and functional proteins. In particular, GenWay has the capability and vector systems for expression of difficult proteins such as proteases, kinases, glycosylated and membrane proteins. We have a very high success rate (almost 100%) and can deliver the proteins in a timely fashion. This is a core competency necessary for efficient and effective production of immunogens and affinity ligands for antibody production and purification. GenWay has over 300
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