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| TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B) Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-372-60052 |
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| Related Product Names:
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TAF4B antibody; TAF4B; TAF2C2; TAFII105; TAFII105ALPHA; TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B)
- Mouse monoclonal anti-human TAF4B antibody; Transcription initiation factor TFIID 105 kDa subunit; TAFII-105; TAFII105; PREDICTED: Homo sapiens TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B), mRNA; Transcription initiation factor TFIID subunit 4B |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: TAF4B |
Gene Name Synonym: TAF2C2; TAFII105; TAFII105ALPHA |
Gi #:
113427767 |
NCBI Acc #:
XM_290809.6 |
Swiss Prot Acc #:
Q92750 |
Length (aa): N/A |
Mol. Weight (Da): 91091 |
Chrom Location: N/A |
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 Clone: TAFAD26A
IGG Subclass: IgG1
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility: Filtered through a 0.22 um membrane.
Source/Host: Mouse
Clonality: Monoclonal
Crossreactivity: Human
Format: Mouse monoclonal anti-human TAF4B antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)
Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for TAF4B ANTIBODY: |
| ELISA: Tested |
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| TAF4B ANTIBODY TARGET DESCRIPTION: |
Synonym Names for TAF4B antibody: TAF4B; TAF2C2; TAFII105; TAFII105ALPHA; Mouse monoclonal anti-human TAF4B antibody; Transcription initiation factor TFIID 105 kDa subunit; TAFII-105; TAFII105; PREDICTED: Homo sapiens TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B), mRNA; Transcription initiation factor TFIID subunit 4B
Function: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B cell-specific transcription.
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.
Subcellular Location: Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
Tissue Specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B cells.
Ptm: Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
Similarity: Belongs to the TAF4 family.
Similarity: Contains 1 histone-fold domain.
Similarity: Contains 1 TAFH (NHR1) domain.
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (TAF4B) reacts with human.
OMIM: 601689; gene. [NCBI / EBI]
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for TAF4B ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Wu Y., Lu Y., Hu Y., Li R.
Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line.
[2] Dikstein R., Zhou S., Tjian R.
Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.
[3] Wolstein O., Silkov A., Revach M., Dikstein R.
Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription.
[4] Yamit-Hezi A., Nir S., Wolstein O., Dikstein R.
Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes.
[5] Rashevsky-Finkel A., Silkov A., Dikstein R.
A composite nuclear export signal in the TBP-associated factor TAFII105.
[6] Shao H., Revach M., Moshonov S., Tzuman Y., Gazit K., Albeck S., Unger T., Dikstein R.
Core promoter binding by histone-like TAF complexes. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: TAF4B antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of TAF4B antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TAF4B antibody, all related information, articles, resources about TAF4B antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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