FALZ antibody, bromodomain PHD finger transcription factor (BPTF),transcript variant 1 Antibody, Mouse Monoclonal Antibody

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bromodomain PHD finger transcription factor (BPTF),transcript variant 1 Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-372-60170

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Related Product Names:

- FALZ antibody; FALZ; BPTF;FAC1; NURF301; bromodomain PHD finger transcription factor (BPTF),transcript variant 1
- Mouse monoclonal anti-human FALZ antibody; Bromodomain and PHD finger-containing transcription factor; Fetal Alzheimer antigen; Fetal Alz-50 clone 1 protein; Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA; Nucleosome-remodeling factor subunit BPTF

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: FALZ	Gene Name Synonym: BPTF;FAC1; NURF301
Gi #: 119395731	NCBI Acc #: NM_182641.3	Swiss Prot Acc #: Q12830
Length (aa): N/A	Mol. Weight (Da): 324219	Chrom Location: N/A

Clone: 2343C3a

IGG Subclass: IgG1

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Mouse monoclonal anti-human FALZ antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)

Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for FALZ ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-FALZ )

FALZ antibody tern B image
FALZ

FALZ ANTIBODY TARGET DESCRIPTION:

Synonym Names for FALZ antibody: FALZ; BPTF;FAC1; NURF301; Mouse monoclonal anti-human FALZ antibody; Bromodomain and PHD finger-containing transcription factor; Fetal Alzheimer antigen; Fetal Alz-50 clone 1 protein; Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA; Nucleosome-remodeling factor subunit BPTF

Function: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.

Subunit: Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3-K4Me3 and to a lesser extent with histone H3-K4Me2.

Subcellular Location: Cytoplasm. Nucleus. Note=In brains of Alzheimer disease patients, present in a subset of amyloid-containing plaques.

Tissue Specificity: Ubiquitously expressed, with highest levels in testis. Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex (at protein level).

Developmental Stage: Abundantly expressed in the fetal brain. Present throughout the gray and white matter of the developing spinal cord at 18-22 gestational weeks. Expressed at low levels in adult brain and spinal cord and reexpressed in neurodegenerative diseases (at protein level).

Domain: The second PHD-type zinc finger mediates binding to histone H3-K4Me3.

Ptm: Phosphorylation enhances DNA-binding. Phosphorylated upon DNA damage, probably by ATM or ATR.

Miscellaneous: Highly susceptible to proteolysis.

Similarity: Belongs to the PBTF family.

Similarity: Contains 1 bromo domain.

Similarity: Contains 1 DDT domain.

Similarity: Contains 2 PHD-type zinc fingers.

Summary: This protein was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.

bromodomain PHD finger transcription factor (BPTF),transcript variant 1 reacts with human.

OMIM: 601819; gene. [NCBI / EBI]

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for FALZ ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Olsen,J.V., Blagoev,B., Gnad,F., Macek,B., Kumar,C., Mortensen,P. and Mann,M.
     Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
[2] Li,H., Ilin,S., Wang,W., Duncan,E.M., Wysocka,J., Allis,C.D. and Patel,D.J.
     Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
[3] Wysocka,J., Swigut,T., Xiao,H., Milne,T.A., Kwon,S.Y., Landry,J., Kauer,M., Tackett,A.J., Chait,B.T., Badenhorst,P., Wu,C. and, et al.
     A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
[4] Strachan,G.D., Ostrow,L.A. and Jordan-Sciutto,K.L., et al.
     Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death
[5] Strachan,G.D., Morgan,K.L., Otis,L.L., Caltagarone,J., Gittis,A., Bowser,R. and Jordan-Sciutto,K.L.
     Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein
[6] Bowser R., Giambrone A., Davies P.
     FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain.
[7] Jones M.H., Hamana N., Shimane M.
     Identification and characterization of BPTF, a novel bromodomain transcription factor.
[8] Barak O., Lazzaro M.A., Lane W.S., Speicher D.W., Picketts D.J., Shiekhattar R.
     Isolation of human NURF: a regulator of Engrailed gene expression.
[9] Mu X., Springer J.E., Bowser R.
     FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord.
[10] Jordan-Sciutto K.L., Dragich J.M., Bowser R.
     DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: FALZ antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of FALZ antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about FALZ antibody, all related information, articles, resources about FALZ antibody are being stored on our online database. Let us know if you have questions regarding this product.

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