CBL antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) Antibody, Mouse Monoclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-372-60174

Buy CBL antibody -

Size:

Related Product Names:

- CBL antibody; CBL; CBL2; C-CBL; RNF55; Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL)
- Mouse monoclonal anti-human CBL antibody; EC 6.3.2.-; Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55; Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL), mRNA; E3 ubiquitin-protein ligase CBL

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CBL	Gene Name Synonym: CBL2; C-CBL; RNF55
Gi #: 52426744	NCBI Acc #: NM_005188.2	Swiss Prot Acc #: P22681
Length (aa): N/A	Mol. Weight (Da): 99647	Chrom Location: N/A

Clone: 2111C3a

IGG Subclass: IgG1

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Mouse monoclonal anti-human CBL antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)

Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CBL ANTIBODY:

DB, WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-CBL )

CBL antibody tern B image
CBL

Western Blot ( anti-CBL )

CBL antibody tern B image
CBL

CBL ANTIBODY TARGET DESCRIPTION:

Synonym Names for CBL antibody: CBL; CBL2; C-CBL; RNF55; Mouse monoclonal anti-human CBL antibody; EC 6.3.2.-; Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto-oncogene; RING finger protein 55; Homo sapiens Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL), mRNA; E3 ubiquitin-protein ligase CBL

Function: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Pathway: Ubiquitin conjugation; third step.

Subunit: Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1. Interacts with phosphorylated LAT2. May interact with CBLB (By similarity).

Subcellular Location: Cytoplasm.

Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.

Domain: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

Ptm: Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70 (By similarity). Phosphorylated on tyrosine residues by INSR.

Disease: Can be converted to an oncogenic protein by deletions or mutations that disturb its ability to down-regulate RTKs.

Miscellaneous: This protein has one functional calcium-binding site.

Similarity: Contains 1 CBL N-terminal domain.

Similarity: Contains 2 EF-hand-like domains.

Similarity: Contains 1 RING-type zinc finger.

Similarity: Contains 1 SH2 domain.

Similarity: Contains 1 UBA domain.

Summary: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) reacts with human.

OMIM: 165360; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Chronic myeloid leukemia 05220
KEGG pathway: ErbB signaling pathway 04012
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Jak-STAT signaling pathway 04630
KEGG pathway: T cell receptor signaling pathway 04660

Products similar to CBL antibody:

IgG

CBL, IgG

DCBLD2, IgG

Rabbit anti Cbl, IgG

CBL, IgG

CBLL1 (Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1), IgG

Protein

Kynurenine--oxoglutarate transaminase 1, Protein

PRODUCT INTERACTIONS:

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF R, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (ready-to-use), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [ICR10], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [Cocktail R19/48 (111.6 + 199.12 + F4 + 11E8)], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [199.12], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [2E9], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with Acitve EGF Receptor EIA Kit, ELISA_Kits (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Ser1070), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr1092), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Thr678), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Thr693), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr1172), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr1197), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr869), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (phospho-Tyr1110), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-1070), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-1092), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-678), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-693), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-1172), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-1197), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-869), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Ab-1110), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Ser1070) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr1092) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR(Phospho-Tyr1172) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr1197) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Phospho-Tyr869) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (phospho-Tyr1110) Antibody Blocking Peptide, Peptide (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (External Domain), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (Internal Domain), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR pTyr 845, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR (a.a. 1165-1186), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR dpTyr 1173, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR, Activated pTyr 1173, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR pS1047, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR pThr 654, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR, pTyr 1045, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF Receptor (non-ligand binding site), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF Receptor (ligand binding site), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF Receptor, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with Rabbit anti EGFR (a.a. 1168-1181), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with Rabbit anti EGF Receptor, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR Human Sf9, Protein (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR Human, Protein (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR Human Sf9, Protein (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with Anti-Epidermal Growth Factor Receptor (EGFR) pY1197, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [ICR10] (FITC), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [29.1], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y1148, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [SP9] (ready-to-use), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [EGFR1], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF R, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y1173, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y1068, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y845, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [F4], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [ICR61], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [R19/48], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [H9B4], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [F4], IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y1086, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR phospho Y992, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGFR [F4] (FITC), IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with EGF R, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with epidermal growth factor receptor isoform a precursor, IgG (GenWay Catalog #: 20-372-60174).

Cas-Br-M (murine) ecotropic retroviral transforming sequence (CBL) interacts with KH domain-containing, RNA-binding, signal transduction-associated protein 1, IgG (GenWay Catalog #: 20-372-60174).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CBL ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Swaminathan,G., Feshchenko,E.A. and Tsygankov,A.Y., et al.
     c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl
[2] Singh,A.J., Meyer,R.D., Navruzbekov,G., Shelke,R., Duan,L., Band,H., Leeman,S.E. and Rahimi,N.
     A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis
[3] Lock,P., I,S.T., Straffon,A.F., Schieb,H., Hovens,C.M. and Stylli,S.S.
     Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination
[4] Lennartsson,J., Wardega,P., Engstrom,U., Hellman,U. and Heldin,C.H., et al.
     Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation
[5] Guenou,H., Kaabeche,K., Dufour,C., Miraoui,H. and Marie,P.J., et al.
     Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation
[6] Blake T.J., Shapiro M., Morse H.C. III, Langdon W.Y.
     The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.
[7] Joazeiro C.A., Wing S.S., Huang H.-K., Leverson J.D., Hunter T., Liu Y.-C.
     The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
[8] Galisteo M.L., Dikic I., Batzer A.G., Langdon W.Y., Schlessinger J.
     Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
[9] Lupher M.L. Jr., Songyang Z., Shoelson S.E., Cantley L.C., Band H.
     The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
[10] Deckert M., Elly C., Altman A., Liu Y.C.
     Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CBL antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CBL antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CBL antibody, all related information, articles, resources about CBL antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved