CHD3 antibody, chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA Antibody, Mouse Monoclonal Antibody

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chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-372-60189

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Related Product Names:

- CHD3 antibody; CHD3; ZFH; Mi-2a; Mi2-ALPHA; chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA
- Mouse monoclonal anti-human CHD3 antibody; EC 3.6.1.-; ATP-dependent helicase CHD3; CHD-3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH; Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA; Chromodomain-helicase-DNA-binding protein 3

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CHD3	Gene Name Synonym: ZFH; Mi-2a; Mi2-ALPHA
Gi #: 52630325	NCBI Acc #: NM_001005273.1	Swiss Prot Acc #: Q12873
Length (aa): N/A	Mol. Weight (Da): 226592	Chrom Location: N/A

Clone: 2172C1a

IGG Subclass: IgG1

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Mouse monoclonal anti-human CHD3 antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)

Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CHD3 ANTIBODY:

DB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-CHD3 )

CHD3 antibody tern B image
CHD3

CHD3 ANTIBODY TARGET DESCRIPTION:

Synonym Names for CHD3 antibody: CHD3; ZFH; Mi-2a; Mi2-ALPHA; Mouse monoclonal anti-human CHD3 antibody; EC 3.6.1.-; ATP-dependent helicase CHD3; CHD-3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH; Homo sapiens chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA; Chromodomain-helicase-DNA-binding protein 3

Function: Probable transcription regulator.

Subunit: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts via its C-terminal region with HABP4.

Subcellular Location: Nucleus.

Tissue Specificity: Widely expressed.

Disease: One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.

Similarity: Belongs to the SNF2/RAD54 helicase family.

Similarity: Contains 2 chromo domains.

Similarity: Contains 1 helicase ATP-binding domain.

Similarity: Contains 1 helicase C-terminal domain.

Similarity: Contains 2 PHD-type zinc fingers.

Summary: This protein is a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

chromodomain helicase DNA binding protein 3 (CHD3), transcript variant 1, mRNA reacts with human.

OMIM: 602120; gene. [NCBI / EBI]

Products similar to CHD3 antibody:

IgG

zinc finger E-box binding homeobox 1 (ZEB1), IgG

ZFHX1B, IgG

AT-binding transcription factor 1 (ATBF1), IgG

AREB6, IgG

PRODUCT INTERACTIONS:

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CHD3 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Pastorcic,M. and Das,H.K., et al.
     The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene
[2] Olsen,J.V., Blagoev,B., Gnad,F., Macek,B., Kumar,C., Mortensen,P. and Mann,M.
     Global, in vivo, and site-specific phosphorylation dynamics in signaling networks
[3] Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H., Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,, et al.
     A human protein-protein interaction network: a resource for annotating the proteome
[4] Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E., Lamond,A.I. and Mann,M.
     Nucleolar proteome dynamics
[5] Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M., Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,, et al.
     A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease
[6] Aubry F., Mattei M.-G., Galibert F.
     Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family.
[7] Woodage T., Basrai M.A., Baxevanis A.D., Hieter P., Collins F.S.
     Characterization of the CHD family of proteins.
[8] Ge Q., Nilasena D.S., O'Brien C.A., Frank M.B., Targoff I.N.
     Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen.
[9] Schultz D.C., Friedman J.R., Rauscher F.J. III
     Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
[10] Lemos T.A., Passos D.O., Nery F.C., Kobarg J.
     Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.

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Precautions: CHD3 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CHD3 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CHD3 antibody, all related information, articles, resources about CHD3 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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