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| SMAD family member 1 (SMAD1), transcript variant 1 Antibody, Mouse Monoclonal Antibody |
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| Catalog Number: 20-372-60280 |
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| Related Product Names:
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SMAD1 antibody; SMAD1; BSP1; JV41; JV4-1;MADH1; MADR1; SMAD family member 1 (SMAD1), transcript variant 1
- Mouse monoclonal anti-human SMAD1 antibody; SMAD 1; Mothers against DPP homolog 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1; BSP-1; hSMAD1; JV4-1; Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1, mRNA; Mothers against decapentaplegic homolog 1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: SMAD1 |
Gene Name Synonym: BSP1; JV41; JV4-1;MADH1; MADR1 |
Gi #:
51173725 |
NCBI Acc #:
NM_005900.2 |
Swiss Prot Acc #:
Q15797 |
Length (aa): N/A |
Mol. Weight (Da): 52260 |
Chrom Location: N/A |
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 Clone: 913C1b
IGG Subclass: IgG1
Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility: Filtered through a 0.22 um membrane.
Source/Host: Mouse
Clonality: Monoclonal
Crossreactivity: Human
Format: Mouse monoclonal anti-human SMAD1 antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)
Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for SMAD1 ANTIBODY: |
| DB, RIA, WB: Tested |
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| TESTING: (secondary reagents and protocols
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Western Blot ( anti-SMAD1 )SMAD1 antibody tern B image
 Western Blot ( anti-SMAD1 )SMAD1 antibody tern B image
 Western Blot ( anti-SMAD1 )SMAD1 antibody tern B image
 Western Blot ( anti-SMAD1 )SMAD1 antibody tern B image
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| SMAD1 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for SMAD1 antibody: SMAD1; BSP1; JV41; JV4-1;MADH1; MADR1; Mouse monoclonal anti-human SMAD1 antibody; SMAD 1; Mothers against DPP homolog 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1; BSP-1; hSMAD1; JV4-1; Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1, mRNA; Mothers against decapentaplegic homolog 1
Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).
Subunit: Interacts with HGS and NANOG (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8.
Subcellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Ptm: Phosphorylated on serine by BMP type 1 receptor kinase.
Ptm: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
Similarity: Belongs to the dwarfin/SMAD family.
Similarity: Contains 1 MH1 (MAD homology 1) domain.
Similarity: Contains 1 MH2 (MAD homology 2) domain.
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
SMAD family member 1 (SMAD1), transcript variant 1 reacts with human.
OMIM: 601595; gene. [NCBI / EBI]
Pathways:
KEGG pathway: TGF-beta signaling pathway 04350
Products similar to SMAD1 antibody:
IgG
 SMAD1 (SMAD family member 1), IgG
SMAD1 (SMAD family member 1), IgG
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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| BACKGROUND
REFERENCES for SMAD1 ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
[1] Shen,Z.J., Kim,S.K., Jun do,Y., Park,W., Kim,Y.H., Malter,J.S. and Moon,B.J.
Antisense targeting of TGF-beta1 augments BMP-induced upregulation of osteopontin, type I collagen and Cbfa1 in human Saos-2 cells
[2] Duan,X., Liang,Y.Y., Feng,X.H. and Lin,X., et al.
Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway
[3] Qiao,J., Kang,J., Ko,T.C., Evers,B.M. and Chung,D.H., et al.
Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway
[4] Liu,Z., Tang,Y., Qiu,T., Cao,X. and Clemens,T.L., et al.
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
[5] Miyoshi,T., Otsuka,F., Suzuki,J., Takeda,M., Inagaki,K., Kano,Y., Otani,H., Mimura,Y., Ogura,T. and Makino,H.
Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells
[6] Riggins G.J., Thiagalingam S., Rosenblum E., Weinstein C.L., Kern S.E., Hamilton S.R., Willson J.K.V., Markowitz S.D., Kinzler K.W., Vogelstein B.V., et al.
Mad-related genes in the human.
[7] Liu F., Hata A., Baker J.C., Doody J., Carcamo J., Harland R.M., Massague J.
A human Mad protein acting as a BMP-regulated transcriptional activator.
[8] Hoodless P.A., Haerry T., Abdollah S., Stapleton M., O'Connor M.B., Attisano L., Wrana J.L.
MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
[9] Lechleider R.J., de Caestecker M.P., Dehejia A., Polymeropoulos M.H., Roberts A.B.
Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
[10] Zhang Y., Feng X.-H., Wu R.-Y., Derynck R.
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. |
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: SMAD1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of SMAD1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about SMAD1 antibody, all related information, articles, resources about SMAD1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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