MYCN antibody, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) Antibody, Mouse Monoclonal Antibody

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v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-372-60298

Buy MYCN antibody -

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Related Product Names:

- MYCN antibody; MYCN; ODED; MODED; N-myc; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
- Mouse monoclonal anti-human MYCN antibody; N/A; Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), mRNA (cDNA clone MGC:3962 IMAGE:3627330), complete cds; N-myc proto-oncogene protein

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: MYCN	Gene Name Synonym: ODED; MODED; N-myc
Gi #: 33877057	NCBI Acc #: BC002712.2	Swiss Prot Acc #: P04198
Length (aa): N/A	Mol. Weight (Da): 49561	Chrom Location: N/A

Clone: 986C1a

IGG Subclass: IgG1

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

Sterility: Filtered through a 0.22 um membrane.

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Mouse monoclonal anti-human MYCN antibody in PBS (3.0 mM KCl, 1.5 mM K2HPO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)

Storage: Store at 2-8 C for up to one year. We recommend storing at –20 C for long-term storage. Avoid repeat freezing and thawing cycles.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for MYCN ANTIBODY:

DB: Tested

TESTING: (secondary reagents and protocols )

Western Blot ( anti-MYCN )

MYCN antibody tern B image
MYCN

MYCN ANTIBODY TARGET DESCRIPTION:

Synonym Names for MYCN antibody: MYCN; ODED; MODED; N-myc; Mouse monoclonal anti-human MYCN antibody; N/A; Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), mRNA (cDNA clone MGC:3962 IMAGE:3627330), complete cds; N-myc proto-oncogene protein

Function: May function as a transcription factor.

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an heterodimer with MAX. Interacts with JARID1A and JARID1B.

Subcellular Location: Nucleus.

Developmental Stage: Expressed during fetal development.

Disease: Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma where the level of amplification appears to increase as the tumor progresses.

Disease: Defects in MYCN are the cause of Feingold syndrome [MIM:164280]; also known as oculodigitoesophagoduodenal syndrome (ODED). Feingold syndrome is characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability and limb malformations. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.

Disease: Defects in MYCN are the cause of microcephaly and digital abnormalities with normal intelligence [MIM:602585].

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain.

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) reacts with human.

OMIM: 164280; phenotype. [NCBI / EBI]
164840; gene. [NCBI / EBI]
602585; phenotype. [NCBI / EBI]

Products similar to MYCN antibody:

IgG

MYCN (v-myc myelocytomatosis viral related oncogene. neuroblastoma derived (avian)), IgG

n-Myc [NCM II 100], IgG

D type cyclin [94B], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for MYCN ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,, et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
[2] Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,, et al.
     Direct Submission
[3] Stanton L.W., Schwab M., Bishop J.M.
     Nucleotide sequence of the human N-myc gene.
[4] Kohl N.E., Legouy E., DePinho R.A., Nisen P.D., Smith R.K., Gee C.E., Alt F.W.
     Human N-myc is closely related in organization and nucleotide sequence to c-myc.
[5] Ibson J.M., Rabbitts P.H.
     Sequence of a germ-line N-myc gene and amplification as a mechanism of activation.
[6] Stanton L.W., Bishop J.M.
     Alternative processing of RNA transcribed from NMYC.
[7] Slamon D.J., Boone T.C., Seeger R.C., Keith D.E., Chazin V., Lee H.C., Souza L.M.
     Identification and characterization of the protein encoded by the human N-myc oncogene.
[8] Michitsch R.W., Melera P.W.
     Nucleotide sequence of the 3' exon of the human N-myc gene.
[9] Hagiwara T., Nakaya K., Nakamura Y., Nakajima H., Nishimura S., Taya Y.
     Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II.
[10] Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P.
     Large-scale characterization of HeLa cell nuclear phosphoproteins.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: MYCN antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of MYCN antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about MYCN antibody, all related information, articles, resources about MYCN antibody are being stored on our online database. Let us know if you have questions regarding this product.

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