PCNA antibody, NUCLEAR ANTIGEN Antibody, Mouse Monoclonal Antibody

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NUCLEAR ANTIGEN Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-783-73547

Buy PCNA antibody -

Size:

Related Product Names:

- PCNA antibody; PCNA; NUCLEAR ANTIGEN
- MOUSE ANTI HUMAN NUCLEAR ANTIGEN; Proliferating cell nuclear antigen

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: PCNA	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_002583.1	Swiss Prot Acc #: N/A
Length (aa): N/A	Mol. Weight (Da): 28769	Chrom Location: N/A

Specificity: NUCLEAR ANTIGEN

Isotype: Specificity: NUCLEAR ANTIGEN

Clone: 21NC85

Immunogen: Native

Specificity Note: This product is histone specific, it stains nuclei and chromosomes of cells from all species including animals and plants. It reacts preferentially with histone H1 by ELISA and immunoblotting. Stains nuclei of all human cell types and also stains chromosomes diffusely in metaphase cells. Intense diffuse staining is obtained in interphase cells.

Histology: Human Tonsil

Preparation: Ig fraction prepared by ammonium sulphate precipitation

Buffer Solution: Phosphate buffered saline, pH 7.2

Preservative Stabilisers:

0.09%

Sodium Azide (NaN₃)

Suggested Dilution: Suggested Dilution: Immunofluorescence - 1/20 - 1/30

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Reacts with: Rat N.B.Antibody reactivity and working conditions may vary betwen species.

Format: Ig Fraction

Storage: Store at +4 degree C or at -20 degree C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Stability: 18 months from date of despatch.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for PCNA ANTIBODY:

IHC-F, ELISA, IF, IHC-P, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

PCNA ANTIBODY TARGET DESCRIPTION:

Synonym Names for PCNA antibody: PCNA; MOUSE ANTI HUMAN NUCLEAR ANTIGEN; Proliferating cell nuclear antigen

Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

Subunit: Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4.

Subcellular Location: Nucleus.

Ptm: Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligase SHPRH, whih is required for DNA repair.

Disease: Antibodies are present in sera from patients with systemic lupus erythematosus.

Similarity: Belongs to the PCNA family.

NUCLEAR ANTIGEN reacts with reacts with: rat n.b.antibody reactivity and working conditions may vary betwen species..

OMIM: 176740; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cell cycle 04110
Reactome Event:Cell Cycle, Mitotic 69278
Reactome Event:DNA Repair 73894
Reactome Event:DNA Replication 69306
Reactome Event:Telomere Maintenance 157579

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PCNA (ready-to-use), IgG

p37 [1320], IgG

PCNA [PC10], IgG

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: PCNA antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of PCNA antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PCNA antibody, all related information, articles, resources about PCNA antibody are being stored on our online database. Let us know if you have questions regarding this product.

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