GRIN1 antibody, NMDA, NR1, N1 Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

NMDA, NR1, N1 Antibody, Rabbit Polyclonal Antibody

Catalog Number: 20-783-73746

Buy GRIN1 antibody -

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Related Product Names:

- GRIN1 antibody; GRIN1; NMDAR1; NMDA, NR1, N1
- RABBIT ANTI NMDA RECEPTOR, NR1 SUBUNIT, SPLICE VARIANT N1; NMDA receptor; Glutamate [NMDA] receptor subunit zeta-1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: GRIN1	Gene Name Synonym: NMDAR1
Gi #: 307303	NCBI Acc #: AAA21180.1	Swiss Prot Acc #: N/A
Length (aa): N/A	Mol. Weight (Da): 105373	Chrom Location: N/A

Specificity: NMDA, NR1, N1

Isotype: Specificity: NMDA, NR1, N1

Immunogen: Synthetic peptide from rat NMDA receptor NR1 subunit, containing the N1 splice variant insert.

Antiserum Preparation: Antisera to rat NMDA receptor. NR1 subunit. splice variant N1 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Preservative Stabilisers: None present

Reconstitution: Reconstitute with 50 ul phosphate buffered saline

Product Note: Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It's recommended that the vial is gently mixed after reconstitution.

For long term storage the addition of 0.09% sodium azide is recommended.
N.B. For functional studies do not add azide.

Suggested Dilution: Western Blot: This product detects a band of approximately 120kDa in HEK293 cell lysates.

Suggested Dilution: Western Blotting - 1:1000

Source/Host: Rabbit

Clonality: Polyclonal

Crossreactivity: Target Species: Rat
Reacts with: MouseBased on sequence similarity, is expected to react with: Human. Chicken. Monkey. Dog. Xenopus N.B.

Format: Purified

Storage: Prior to reconstitution store at +4 degree C.
After reconstitution store at -20 degree C.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Stability: 12 months from date of reconstitution.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for GRIN1 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Western Blot: Detects a band of approximately 120kDa in HEK293 cell lysates. ( anti-GRIN1 )

GRIN1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for GRIN1 antibody: GRIN1; NMDAR1; RABBIT ANTI NMDA RECEPTOR, NR1 SUBUNIT, SPLICE VARIANT N1; NMDA receptor; Glutamate [NMDA] receptor subunit zeta-1

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).

Subcellular Location: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).

Ptm: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family [view classification].

NMDA, NR1, N1 reacts with target species: rat
reacts with: mousebased on sequence similarity, is expected to react with: human. chicken. monkey. dog. xenopus n.b..

OMIM: 138249; gene. [NCBI / EBI]

Products similar to GRIN1 antibody:

IgG

NMDA receptor 1 / GRIN1, IgG

NMDAR,NR1,C2', IgG

Glutamate [NMDA] receptor subunit zeta 1, IgG

Glutamate, IgG

Peptide

NMDAR1 (Phospho-Ser896) Antibody Blocking Peptide, Peptide

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for GRIN1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

1. Ishii. T. et al. (1993) Molecular characterization of the family of the N-Methyl-D-Aspartate receptor subunits. 2. Ehlers. M.D. et al. (1998) Splice variant-specific interaction of the NMDA receptor subunit NR1 with neuronal intermediate filaments.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: GRIN1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of GRIN1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GRIN1 antibody, all related information, articles, resources about GRIN1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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