CFH antibody, FACTOR H Antibody, Mouse Monoclonal Antibody

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FACTOR H Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-783-75016

Buy CFH antibody -

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Related Product Names:

- CFH antibody; CFH; HF; HF1; HF2; FACTOR H
- MOUSE ANTI HUMAN FACTOR H; Complement factor H

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: CFH	Gene Name Synonym: HF; HF1; HF2
Gi #: N/A	NCBI Acc #: NP_000177.2	Swiss Prot Acc #: N/A
Length (aa): N/A	Mol. Weight (Da): 139096	Chrom Location: N/A

Specificity: FACTOR H

Isotype: Specificity: FACTOR H

Clone: OX-24

Immunogen: Human complement factor H

Fusion Partner: NS-O myeloma fused with spleen cells from BALB/c mice.

Specificity Note: This product recognises the human serum complement protein factor H (155kD), binding to a different epitope from MRC OX23. The antibody also recognises a 43-49kD truncated form of factor H present at low level (1-5 ug/ml) in plasma and urine. In an immunoprecipitation system, it recognises factor H in other primates, but not in cow, sheep, pig, chicken or rabbit sera.

This antibody inhibits the binding of factor H to surface bound C3b, and recognises Factor H in Western blotting procedures.

Preservative Stabilisers:

0.09%

Sodium Azide

Source/Host: Mouse

Clonality: Monoclonal

Crossreactivity: Human

Format: Purified

Storage: Store at +4 degree C or at -20 degree C if preferred.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Stability: 18 months from date of despatch.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for CFH ANTIBODY:

ELISA, IP, WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

CFH ANTIBODY TARGET DESCRIPTION:

Synonym Names for CFH antibody: CFH; HF; HF1; HF2; MOUSE ANTI HUMAN FACTOR H; Complement factor H

Function: Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.

Subcellular Location: Secreted.

Tissue Specificity: Expressed by the liver and secreted in plasma.

Disease: Genetic variations in CFH are associated with basal laminar drusen [MIM:126700]; also known as drusen of Bruch membrane or cuticular drusen or grouped early adult-onset drusen. Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.

Disease: Defects in CFH are the cause of complement factor H deficiency (CFH deficiency) [MIM:609814]. CFH deficiency determines uncontrolled activation of the alternative complement pathway with consumption of C3 and often other terminal complement components. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome. CFH deficiency patients may show increased susceptibility to meningococcal infections.

Disease: Defects in CFH are a cause of hemolytic-uremic syndrome (HUS) [MIM:235400]. HUS is a microvasculature disorder leading to microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells'), thrombocytopenia, and acute renal failure. Both dominant and recessive modes of inheritance have been reported. Most cases of HUS are associated with epidemics of diarrhea caused by verocytotoxin-producing bacteria, but atypical cases of HUS not associated with diarrhea (aHUS) also occur.

Disease: Genetic variation in CFH is associated with age-related macular degeneration type 4 (ARMD4) [MIM:610698]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Similarity: Contains 20 Sushi (CCP/SCR) domains.

FACTOR H reacts with human.

OMIM: 126700; phenotype. [NCBI / EBI]
134370; gene. [NCBI / EBI]
235400; phenotype. [NCBI / EBI]
609814; phenotype. [NCBI / EBI]
610698; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Complement and coagulation cascades 04610

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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for CFH ANTIBODY:

Background references for antibody target are not specific to GenWay products

1. Alsenz. J. et al. (1985) Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to Factor H. 2. Fontaine. M. et al. (1989) Truncated forms of human complement factor H. 3. Sim. E. et al. (1983) Monoclonal antibodies against the complement control protein factor h (beta IH). Biosci. Rep. 3: 1119-1131.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: CFH antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of CFH antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about CFH antibody, all related information, articles, resources about CFH antibody are being stored on our online database. Let us know if you have questions regarding this product.

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