|
|
| ALPHA SYNUCLEIN Antibody, Goat Polyclonal Antibody |
 |
|
|
 |
| Catalog Number: 18-783-76340 |
|
|
|
| Related Product Names:
|
-
ALPHA SYNUCLEIN antibody; ALPHA SYNUCLEIN
- GOAT ANTI HUMAN ALPHA SYNUCLEIN; Alpha-synuclein isoform NACP140; N/A |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: N/A |
Gene Name Synonym: N/A |
Gi #:
4507109 |
NCBI Acc #:
NP_000336.1 |
Swiss Prot Acc #:
P37840 |
Length (aa): N/A |
Mol. Weight (Da): N/A |
Chrom Location: N/A |
|
|
 Specificity: ALPHA SYNUCLEIN
NCBI Gene ID: 6622
Isotype: Specificity: ALPHA SYNUCLEIN
Immunogen: Synthetic peptide corresponding to amino acids 116-131 of the C-terminus of a synuclein
Specificity Note: This product recognises human alpha-synuclein.
The alpha-synuclein gene, located on chromosome 4, has been linked to early onset autosomal dominant Parkinson's disease.
The protein is abundant in the nervous system, and is known to be the precursor of the non-beta amyloid component protein (NACP) of Alzheimer's disease. Alpha-synuclein has also been found to be associated with other neurodegenerative diseases such as multiple system atrophy and dementia with Lewy's bodies.
Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Histology: Brain, Spinal Cord.
Antiserum Preparation: Antisera to a-synuclein were raised by repeated immunisation of goats with highly purified antigen.
Preservative Stabilisers:
Suggested Dilution: Suggested Dilution: Immunohistology - Paraffin - 1/300
Immunohistology - Resin - 1/1000 vs immunising peptide
Source/Host: Goat
Clonality: Polyclonal
Crossreactivity: Human
Format: Serum
Storage: Store at +4 degree C or at -20 degree C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability: 18 months from date of despatch.
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for ALPHA SYNUCLEIN ANTIBODY: |
| ELISA, IHC-F: Tested |
|
|
|
|
| ALPHA SYNUCLEIN ANTIBODY TARGET DESCRIPTION: |
Synonym Names for ALPHA SYNUCLEIN antibody: N/A; GOAT ANTI HUMAN ALPHA SYNUCLEIN; Alpha-synuclein isoform NACP140; N/A
Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined.
Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced transcripts of SNCA have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. [provided by RefSeq].
ALPHA SYNUCLEIN reacts with human.
OMIM: NCBI [163890]
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
| BACKGROUND
REFERENCES for ALPHA SYNUCLEIN ANTIBODY: |
| Background references for antibody target are not specific to GenWay products |
| 1. Spillantini. M.G. et al. (1997) Alpha-synuclein in Lewy bodies 2. Gai. W.P. et al. (1997) Multiple-system atrophy: a new alpha-synuclein disease. |
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: ALPHA SYNUCLEIN antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of ALPHA SYNUCLEIN antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ALPHA SYNUCLEIN antibody, all related information, articles, resources about ALPHA SYNUCLEIN antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
