Alphabetical Listing of Primary Antibodies:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Alphabetical Listing of Proteins:
f
|
0-4
|
5-9
|
A
|
B
|
C
|
D
|
E
|
F
|
G
|
H
|
I
|
J
|
K
|
L
|
M
|
N
|
O
|
P
|
Q
|
R
|
S
|
T
|
U
|
V
|
W
|
X
|
Y
|
Z
|
Peptides
|
Secondary Antibodies
|
ELISA Kits
ACE 2 Antibody, Rabbit Polyclonal Antibody
Catalog Number: 18-783-76685
Buy ACE2 antibody -
Size:
0.1 mg ($270.00)
Related Product Names:
- ACE2 antibody; ACE2; ACE 2
- RABBIT ANTI HUMAN ACE 2 (N-TERMINAL); Angiotensin-converting enzyme 2
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact
sales@genwaybio.com
.
Gene Name:
ACE2
Gene Name Synonym:
N/A
Gi #:
N/A
NCBI Acc #:
NP_068576.1
Swiss Prot Acc #:
Q9BYF1
Length (aa):
N/A
Mol. Weight (Da):
92463
Chrom Location:
N/A
Specificity:
ACE 2
NCBI Gene ID:
59272
Isotype:
Specificity:
ACE 2
Immunogen: Synthetic peptide corresponding to a sequence within the amino terminus of human ACE2.
Specificity Note: This product is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system.
ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.
A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.
Immunohistology:
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Antiserum Preparation:
Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0.02%
Sodium Azide
Source/Host:
Rabbit
Clonality:
Polyclonal
Crossreactivity:
Human
Format:
Purified
Storage:
Store at +4 degree C or at -20 degree C if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability:
18 months from date of despatch.
Shipping:
Products may be shipped on ice pack or dry ice.
APPLICATIONS for ACE2 ANTIBODY:
IHC-F, WB: Tested
TESTING: (
secondary reagents
and
protocols
)
Not Available
ACE2 ANTIBODY TARGET DESCRIPTION:
Synonym Names for ACE2 antibody:
ACE2; RABBIT ANTI HUMAN ACE 2 (N-TERMINAL); Angiotensin-converting enzyme 2
Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Cofactor:
Binds 1 zinc ion per subunit.
Cofactor:
Binds 1 chloride ion per subunit.
Enzyme Regulation:
Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat.
Biophysicochemical Properties:
Subunit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.
Subcellular Location:
Processed angiotensin-converting enzyme 2: Secreted.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.
Induction:
Up-regulated in failing heart.
Ptm:
N-glycosylation on Asn-90 may limit SARS infectivity.
Similarity:
Belongs to the peptidase M2 family [view classification].
ACE 2 reacts with human.
OMIM:
300335; gene. [
NCBI
/
EBI
]
Pathways:
KEGG pathway: Renin-angiotensin system
04614
Products similar to ACE2 antibody:
IgG
ACE2, IgG
RCE1 (RCE1 homolog. prenyl protein peptidase (S. cerevisiae)), IgG
Angiotensin-converting enzyme 2, IgG
Beta-secretase 2, IgG
Rabbit A' BACE 2 (a.a.496-511), IgG
Peptide
BACE2 (a.a. 44-59) Peptide, Peptide
SUGGESTED ANITBODY REAGENTS
- GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
Order Confirmation:
Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions:
ACE2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes:
During shipment, small volumes of ACE2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright:
This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ACE2 antibody, all related information, articles, resources about ACE2 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer:
For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.
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