|
|
| KAP 1 Antibody, Rabbit Polyclonal Antibody |
 |
|
|
 |
| Catalog Number: 18-783-78703 |
|
|
|
| Related Product Names:
|
-
TRIM28 antibody; TRIM28; KAP1; RNF96; TIF1B; KAP 1
- RABBIT ANTI HUMAN KAP 1; Transcription intermediary factor 1-beta |
|
- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
|
|
| Gene Name: TRIM28 |
Gene Name Synonym: KAP1; RNF96; TIF1B |
Gi #:
N/A |
NCBI Acc #:
NP_005753.1 |
Swiss Prot Acc #:
N/A |
Length (aa): N/A |
Mol. Weight (Da): 88550 |
Chrom Location: N/A |
|
|
 Specificity: KAP 1
Isotype: Specificity: KAP 1
Preservative Stabilisers: None present
Source/Host: Rabbit
Clonality: Polyclonal
Crossreactivity: Human
Format: Purified
Storage: Store at -20 degree C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Stability: 18 months from date of despatch.
Shipping: Products may be shipped on ice pack or dry ice. |
|
| APPLICATIONS for TRIM28 ANTIBODY: |
| WB: Tested |
|
|
|
|
| TRIM28 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for TRIM28 antibody: TRIM28; KAP1; RNF96; TIF1B; RABBIT ANTI HUMAN KAP 1; Transcription intermediary factor 1-beta
Function: Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of the Alpha-1-acid glycoprotein gene (By similarity).
Subunit: Associated with HP1 alpha (CBX5), beta (CBX1) and gamma (CBX3) in interphase nuclei (By similarity). Interacts with NCOR1 and CHD3. Interacts with SETDB1, ZFP53 and ZFP68. Interacts with CEBPB and NR3C1 (By similarity). Interacts directly with CBX5 via the PxVxL motif.
Subcellular Location: Nucleus (By similarity). Note=Associated with centromeric heterochromatin during cell differentiation through CBX1 (By similarity).
Domain: The HP1 box is both necessary and sufficient for HP1 binding. The RING finger domain and the B-box domains mediate interaction with CEBPB. The PHD domain enhances the CEBPB transcriptional activity (By similarity).
Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Ptm: Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity: Belongs to the TRIM/RBCC family.
Similarity: Contains 2 B box-type zinc fingers.
Similarity: Contains 1 bromo domain.
Similarity: Contains 1 PHD-type zinc finger.
Similarity: Contains 1 RING-type zinc finger.
KAP 1 reacts with human.
OMIM: 601742; gene. [NCBI / EBI]
Products similar to TRIM28 antibody:
IgG
 AKAP6, IgG
AKAP12, IgG
AKAP7 (A kinase (PRKA) anchor protein 7), IgG
KAP1, IgG
AKAP12, IgG
|
|
|
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
|
|
Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: TRIM28 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of TRIM28 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about TRIM28 antibody, all related information, articles, resources about TRIM28 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
|
|
|
GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.
|
|
Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
|
|
