G6PD native protein, GLUCOSE-6-PHOSPHATE DEHYDROGENASE native protein

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GLUCOSE-6-PHOSPHATE DEHYDROGENASE native protein

Catalog Number: 11-783-79549

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Related Product Names:

- G6PD native protein; G6PD; GLUCOSE-6-PHOSPHATE DEHYDROGENASE
- NATIVE YEAST GLUCOSE-6-PHOSPHATE DEHYDROGENASE; Glucose-6-phosphate 1-dehydrogenase

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: G6PD	Gene Name Synonym: N/A
Gi #: N/A	NCBI Acc #: NP_000393.4	Swiss Prot Acc #: N/A
Length (aa): N/A	Mol. Weight (Da): 59257	Chrom Location: N/A

Specificity: GLUCOSE-6-PHOSPHATE DEHYDROGENASE

Activity: 538 U/mg protein
350 U/mg material solid. Specific activity is found above.
Hexokinase <0.0063%CK <0.0011%ATPase <0.001%6-Phospho-gluconatedehydrogenase <0.001%PGM <0.0006%PGI <0.0003%

Preservative Stabilisers: None present

Reconstitution: In sterile DI water or dilute buffer of choice.

Product Note: 1 unit is the amount of enzyme which causes the reduction of 1 uM of NADP+ per minute at 25 degree C. pH 8.0.

Crossreactivity: Yeast

Format: Purified

Storage: Prior to reconstitution store at +4 degree C.
After reconstitution store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody.
Should this product contain a precipitate we recommend microcentrifugation before use.

Stability: 18 months from date of despatch.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for G6PD NATIVE PROTEIN:

ELISA: Tested

TESTING: (secondary reagents and protocols )

Not Available

G6PD NATIVE PROTEIN TARGET DESCRIPTION:

Synonym Names for G6PD native protein: G6PD; NATIVE YEAST GLUCOSE-6-PHOSPHATE DEHYDROGENASE; Glucose-6-phosphate 1-dehydrogenase

Function: Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.

Catalytic Activity: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH.

Pathway: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Subunit: Homodimer or homotetramer.

Tissue Specificity: The long isoform is found in lymphoblasts, granulocytes and sperm.

Polymorphism: The sequence shown is that of variant B, the most common variant.

Disease: Defects in G6PD are the cause of chronic non-spherocytic hemolytic anemia (CNSHA) [MIM:305900]. Deficiency of G6PD is associated with hemolytic anemia in two different situations. First, in areas in which malaria has been endemic, G6PD-deficiency alleles have reached high frequencies (1% to 50%) and deficient individuals, though essentially asymptomatic in the steady state, have a high risk of acute hemolytic attacks. Secondly, sporadic cases of G6PD deficiency occur at a very low frequencies, and they usually present a more severe phenotype. Several types of CNSHA are recognized. Class-I variants are associated with severe NSHA; class-II have an activity <10% of normal; class-III have an activity of 10% to 60% of normal; class-IV have near normal activity.

Miscellaneous: Has NADP both as cofactor (bound to the N-terminal domain) and as structural element bound to the C-terminal domain.

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family.

GLUCOSE-6-PHOSPHATE DEHYDROGENASE reacts with yeast.

OMIM: 305900; gene+phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Glutathione metabolism 00480
KEGG pathway: Pentose phosphate pathway 00030
Reactome Event:Metabolism of carbohydrates 71387

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Precautions: G6PD native protein is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of G6PD native protein vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about G6PD native protein, all related information, articles, resources about G6PD native protein are being stored on our online database. Let us know if you have questions regarding this product.

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