ABCA1 antibody, ABCA1 Antibody, Mouse Monoclonal Antibody

Alphabetical Listing of Primary Antibodies:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Alphabetical Listing of Proteins:	f\| 0-4 \| 5-9 \| A \| B \| C \| D \| E \| F \| G \| H \| I \| J \| K \| L \| M \| N \| O \| P \| Q \| R \| S \| T \| U \| V \| W \| X \| Y \| Z \|
Peptides \| Secondary Antibodies \| ELISA Kits

ABCA1 Antibody, Mouse Monoclonal Antibody

Catalog Number: 20-271-80098

Buy ABCA1 antibody -

Size:

Related Product Names:

- ABCA1 antibody; ABCA1; ABC1; CERP; ABCA1
- Mouse Anti ABCA1; ATP-binding cassette transporter 1; ATP-binding cassette 1; ABC-1; Cholesterol efflux regulatory protein; ABCA1; ATP-binding cassette sub-family A member 1

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: ABCA1	Gene Name Synonym: ABC1; CERP
Gi #: 15212107	NCBI Acc #: BAB63210.1	Swiss Prot Acc #: O95477
Length (aa): 2261	Mol. Weight (Da): 254286	Chrom Location: N/A

Clone: A00121.01

IgG Subclass: Mouse Monoclonal IgG1

Immunogen: Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1.

Antigen Species: Human

Conjugation: Unconjugated

Specificity: Recognize specifically ABCA1 from human. mouse. and chicken.

Note: Western blot, ELISA, IP, and IHC in lipid metabolic research. Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.

Application: Use as an antigen in ELISA and Western Blots.

Concentration: Lot specific and is stated on the vial

Applications: WB, ELISA, IP, IHC

Source/Host: Mouse

Purity/Purification: Immunoaffinity purification

Clonality: Monoclonal

Crossreactivity: Human, mouse, and chicken

Format: PBS, pH 7.4 with 0.05% sodium azide, frozen liquid

Storage: The antibody will remain stable for 1 year from the date of shipment if stored at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquots will remain for three months if stored at 4°C.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for ABCA1 ANTIBODY:

IHC, WB, ELISA, IP: Tested

TESTING: (secondary reagents and protocols )

Immunohistochemistry: ( anti-ABCA1 )

ABCA1 antibody Immunohistochemistry image
ABCA1

Western Blot: ( anti-ABCA1 )

ABCA1 antibody Western Blot image
ABCA1

ABCA1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for ABCA1 antibody: ABCA1; ABC1; CERP; Mouse Anti ABCA1; ATP-binding cassette transporter 1; ATP-binding cassette 1; ABC-1; Cholesterol efflux regulatory protein; ABCA1; ATP-binding cassette sub-family A member 1

This membrane-associated protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extracellular and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Function: cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

Tissue Specificity: Widely expressed, but most abundant in macrophages.

Induction: By bacterial lipopolysaccharides (LPS). LPS regulates expression through a liver X receptor (LXR) -independent mechanism. Repressed by ZNF202.

Domain: Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.

Ptm: Phosphorylation on Ser-2054 regulates phospholipid efflux.

Disease: Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.

Disease: Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.

Similarity: Belongs to the ABC transporter family. ABCA subfamily.

Similarity: Contains 2 ABC transporter domains.

ABCA1 reacts with human, mouse, and chicken.

OMIM: 205400; phenotype. [NCBI / EBI]
600046; gene+phenotype. [NCBI / EBI]
604091; phenotype. [NCBI / EBI]

Products similar to ABCA1 antibody:

IgG

TAP1 [53H8], IgG

BCRP [BXP-21], IgG

ATP-binding cassette, sub-family F (GCN20), member 2 (ABCF2), nuclear gene encoding mitochondrial protein, transcript variant 2,, IgG

TAP1, IgG

BCRP [BXP-34], IgG

PRODUCT INTERACTIONS:

ABCA1 interacts with DLG2 (discs. large homolog 2. chapsyn-110 (Drosophila)), IgG (GenWay Catalog #: 20-271-80098).

ABCA1 interacts with SYNTROPHIN ALPHA 1, IgG (GenWay Catalog #: 20-271-80098).

ABCA1 interacts with Syntrophin alpha 1, IgG (GenWay Catalog #: 20-271-80098).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for ABCA1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Tanaka,A.R., Abe-Dohmae,S., Arakawa,R., Sadanami,K., Kidera,A., Kioka,N., Amachi,T., Yokoyama,S. and Ueda,K.
     A new topological model of functional human ABCA1-Signal peptide cleavage and glycosylation of a large extracellular domain
[2] Ueda,K., Kioka,N. and Tanaka,A.R., et al.
     Direct Submission
[3] Santamarina-Fojo S., Peterson K.M., Knapper C.L., Qiu Y., Freeman L.A., Cheng J.-F., Osorio J., Remaley A.T., Yang X.-P., Haudenschild C.C., et al.
     Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter.
[4] Schwartz K., Lawn R.M., Wade D.P.
     ABCA1 gene expression and apoA-I-mediated cholesterol efflux are regulated by LXR.
[5] Qiu Y., Cavelier L., Chiu S., Yang X., Rubin E., Cheng J.-F.
     Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences.
[6] Tanaka A.R., Abe-Dohmae S., Arakawa R., Sadanami K., Kidera A., Kioka N., Amachi T., Yokoyama S., Ueda K.
     A new topological model of functional human ABCA1-signal peptide cleavage and glycosylation of a large extracellular domain.
[7] Langmann T., Klucken J., Reil M., Liebisch G., Luciani M.F., Chimini G., Kaminski W.E., Schmitz G.
     Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.
[8] Rust S., Rosier M., Funke H., Real J., Amoura Z., Piette J.-C., Deleuze J.-F., Brewer H.B. Jr., Duverger N., Denefle P., et al.
     Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1.
[9] See R.H., Caday-Malcolm R.A., Singaraja R.R., Zhou S., Silverston A., Huber M.T., Moran J., James E.R., Janoo R., Savill J.M., et al.
     Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.
[10] Porsch-Oezcueruemez M., Langmann T., Heimerl S., Borsukova H., Kaminski W.E., Drobnik W., Honer C., Schumacher C., Schmitz G.
     The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: ABCA1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of ABCA1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about ABCA1 antibody, all related information, articles, resources about ABCA1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed.

GenWay is a Protein and Antibody Solutions Provider. Customer Satisfaction is Our Top Priority.

Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays.



GenWay Biotech, Inc. 6777 Nancy Ridge Drive, San Diego, CA 92121 Tel: (858)458-0866 Fax: (858)458-0833 Email: sales@genwaybio.com www.genwaybio.com ©1998 - 2010 GenWay Biotech, Inc. - All Rights Reserved