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| PABP Antibody, Mouse IgG2b Monoclonal Antibody |
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| Catalog Number: 20-373-85023 |
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| Related Product Names:
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PABPC1 antibody; PABPC1; PAB1; PABP1; PABPC2; PABP
- Poly(A)-binding protein 1; PABP 1; Polyadenylate-binding protein 1 |
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- Gene Information -
Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.
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| Gene Name: PABPC1 |
Gene Name Synonym: PAB1; PABP1; PABPC2 |
Gi #:
N/A |
NCBI Acc #:
NP_002559.2 |
Swiss Prot Acc #:
P11940 |
Length (aa): N/A |
Mol. Weight (Da): 70671 |
Chrom Location: N/A |
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 Clone Number: 100000000000
Source/Host: Mouse IgG2b
Clonality: Monoclonal
Crossreactivity: Chicken, human, rabbit, xenopus
Format: Purified
Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.
Stability: 6-12 months at -20 degree C.
Shipping: Products may be shipped on ice pack or dry ice. |
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| APPLICATIONS for PABPC1 ANTIBODY: |
| WB , IF, IP , ELISA: Tested |
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| PABPC1 ANTIBODY TARGET DESCRIPTION: |
Synonym Names for PABPC1 antibody: PABPC1; PAB1; PABP1; PABPC2; Poly(A)-binding protein 1; PABP 1; Polyadenylate-binding protein 1
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Subunit: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1 and PAIP2. Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction with CSDE1 is direct and RNA-independent. Found in a mRNP complex with YBX2. Interacts with PAPD4/GLD2. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8 (By similarity). Interacts with NFX1.
Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Specificity: Ubiquitous.
Domain: The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively.
Domain: The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively.
Ptm: Methylated by CARM1.
Ptm: Arg-493 is dimethylated, probably to asymmetric dimethylarginine.
Similarity: Belongs to the polyadenylate-binding protein type-1 family.
Similarity: Contains 1 PABC domain.
Similarity: Contains 4 RRM (RNA recognition motif) domains.
PABP reacts with chicken, human, rabbit, xenopus.
OMIM: 604679; gene. [NCBI / EBI]
Pathways:
Reactome Event:Gene Expression 74160
Reactome Event:Translation 72766
Products similar to PABPC1 antibody:
IgG
 p53 [Pab1801], IgG
PABP, IgG
p53 [Pab1801], IgG
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| PRODUCT INTERACTIONS: |
PABP interacts with DLC8 (N-term), IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with EIF4G phospho S1108, IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with EIF4G1, IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with Inhibitor of nuclear factor kappa-B kinase epsilon subunit, IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with IKK iota + IKK epsilon [72B587], IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with IKK iota + IKK epsilon, IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with Anti-IKKe pT501, IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with NDRG1 (N-myc downstream regulated gene 1), IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with NDRG1 (N-myc downstream regulated gene 1), IgG (GenWay Catalog #: 20-373-85023).
PABP interacts with Recombinant Human N-Myc Downstream Regulated 1, Protein (GenWay Catalog #: 20-373-85023).
PABP interacts with Recombinant Human PIN2-Interacting Protein 1, Protein (GenWay Catalog #: 20-373-85023).
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SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.
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Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.
Precautions: PABPC1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.
Important Notes: During shipment, small volumes of PABPC1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.
Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about PABPC1 antibody, all related information, articles, resources about PABPC1 antibody are being stored on our online database. Let us know if you have questions regarding this product.
Disclaimer: For documents and software available from this server, GenWay neither warrants nor assumes any legal liability or responsibility for the accuracy, completeness or utility of any information, product or process disclosed. |
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Thank you for visiting GenWay Biotech's Datasheet. GenWay is the world's leader in chicken, IgY antibody production, producing over 900 quality polyclonal IgY antibodies to date. From our unique recombinant protein production, utilizing a variety of protein expression systems, GenWay's polyclonal IgY antibodies incorporate more epitopes, increasing the success rate for ELISA, western blot, immunohistochemistry (IHC), immunocytochemistry (ICC), and many more immunoassays. |
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