Kpna2 antibody, Karyopherin (Importin) alpha 2 Antibody, Rat IgG2a Monoclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Karyopherin (Importin) alpha 2 Antibody, Rat IgG2a Monoclonal Antibody

Catalog Number: 20-373-85083

Buy Kpna2 antibody -

Volume:

Related Product Names:

- Kpna2 antibody; Kpna2; Karyopherin (Importin) alpha 2
- Karyopherin alpha 2; Karyopherin (importin) alpha 2 [Rattus norvegicus]

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: Kpna2	Gene Name Synonym: N/A
Gi #: 16758242	NCBI Acc #: NP_445935.1	Swiss Prot Acc #: Q6P6T9
Length (aa): 529	Mol. Weight (Da): 57837	Chrom Location: N/A

Clone Number: 2G7

Source/Host: Rat IgG2a

Clonality: Monoclonal

Crossreactivity: Human

Format: Purified

Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for KPNA2 ANTIBODY:

WB: Tested

TESTING: (secondary reagents and protocols )

Not Available

KPNA2 ANTIBODY TARGET DESCRIPTION:

Synonym Names for Kpna2 antibody: Kpna2; Karyopherin alpha 2; Karyopherin (importin) alpha 2 [Rattus norvegicus]

Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).

Subcellular Location: Cytoplasm (By similarity). Nucleus (By similarity).

Domain: Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import (By similarity).

Domain: The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).

Domain: The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).

Summary: receptor which binds to Glut2; participates in nuclear import [RGD].

Karyopherin (Importin) alpha 2 reacts with human.

Products similar to Kpna2 antibody:

IgG

KPNA2 / IPOA1, IgG

Importin alpha-2 subunit, Protein

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for KPNA2 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Plant,K.E., Everett,D.M., Gordon Gibson,G., Lyon,J. and Plant,N.J., et al.
     Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth
[2] Cassany,A., Guillemain,G., Klein,C., Dalet,V., Brot-Laroche,E. and Leturque,A.
     A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells
[3] Guillemain,G., Munoz-Alonso,M.J., Cassany,A., Loizeau,M., Faussat,A.M., Burnol,A.F. and Leturque,A.
     Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells
[4] Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
     Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
[5] Plant K.E., Everett D.M., Gordon Gibson G., Lyon J., Plant N.J.
     Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth.

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Precautions: Kpna2 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of Kpna2 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about Kpna2 antibody, all related information, articles, resources about Kpna2 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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