GRIN1 antibody, Rabbit Anti-NMDA receptor NR2A Antibody, Rabbit Polyclonal Antibody

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Peptides \| Secondary Antibodies \| ELISA Kits

Rabbit Anti-NMDA receptor NR2A Antibody, Rabbit Polyclonal Antibody

Catalog Number: 18-373-88024

Buy GRIN1 antibody -

Volume:

Related Product Names:

- GRIN1 antibody; GRIN1; NMDAR1; Rabbit Anti-NMDA receptor NR2A
- N-methyl-D-aspartate receptor subunit NR1; NMDA receptor

- Gene Information - Information in yellow represents specific gene information and does not necessarily represent specific product details. For more information please contact sales@genwaybio.com.

Gene Name: GRIN1	Gene Name Synonym: NMDAR1
Gi #: 307303	NCBI Acc #: AAA21180.1	Swiss Prot Acc #: Q05586
Length (aa): 885	Mol. Weight (Da): 105373	Chrom Location: N/A

Immunogen: NR2A (13811394)thyroglobulin conjugate

Specificity: Rat, mouse, human NR2A subunit

Applications: IB; IHC; IP;

Dilutions: Optimal antibody dilution should be determined by titration, however as a guideline try 1:100-1:1000

Source/Host: Rabbit

Purity/Purification: Peptide affinity purified;

Clonality: Polyclonal

Crossreactivity: Human, mouse, rat

Format: Purified antibody in PBS + 0.05% sodium azide;

Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

Stability: 6-12 months at -20 degree C.

Shipping: Products may be shipped on ice pack or dry ice.

APPLICATIONS for GRIN1 ANTIBODY:

WB , IHC, IP: Tested

TESTING: (secondary reagents and protocols )

IHC: ( anti-GRIN1 )

GRIN1 antibody IHC image
GRIN1

GRIN1 ANTIBODY TARGET DESCRIPTION:

Synonym Names for GRIN1 antibody: GRIN1; NMDAR1; N-methyl-D-aspartate receptor subunit NR1; NMDA receptor

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

Subunit: Form heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity).

Subcellular Location: Cell membrane; multi-pass membrane protein (By similarity). Note=Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).

Ptm: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity).

Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10) family [view classification].

Rabbit Anti-NMDA receptor NR2A reacts with human, mouse, rat.

OMIM: 138249; gene. [NCBI / EBI]

Products similar to GRIN1 antibody:

IgG

NMDAR1 (Phospho-Ser896), IgG

NMDAR NR2B, IgG

NMDAR,NR1,C2, IgG

Glutamate, IgG

NMDA receptor 1 / GRIN1, IgG

Peptide

NMDAR1 (Phospho-Ser896) Antibody Blocking Peptide, Peptide

PRODUCT INTERACTIONS:

Rabbit Anti-NMDA receptor NR2A interacts with ErbB4, IgG (GenWay Catalog #: 18-373-88024).

Rabbit Anti-NMDA receptor NR2A interacts with ErbB4 [SPM338] (ready-to-use), IgG (GenWay Catalog #: 18-373-88024).

Rabbit Anti-NMDA receptor NR2A interacts with ErbB4 [H4.77.16], IgG (GenWay Catalog #: 18-373-88024).

Rabbit Anti-NMDA receptor NR2A interacts with ErbB4 (ready-to-use), IgG (GenWay Catalog #: 18-373-88024).

SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more.

BACKGROUND REFERENCES for GRIN1 ANTIBODY:

Background references for antibody target are not specific to GenWay products

[1] Planells-Cases,R., Sun,W., Ferrer-Montiel,A.V. and Montal,M., et al.
     Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain
[2] Karp S.J., Masu M., Eki T., Ozawa K., Nakanishi S.
     Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.
[3] Planells-Cases R., Sun W., Ferrer-Montiel A.V., Montal M.
     Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.
[4] Foldes R.L., Rampersad V., Kamboj R.K.
     Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing.
[5] Zimmer M., Fink T.M., Franke Y., Lichter P., Spiess J.
     Cloning and structure of the gene encoding the human N-methyl-D-aspartate receptor (NMDAR1).
[6] Foldes R.L., Rampersad V., Kamboj R.K.
     Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits.
[7] Younkin D.P., Tang C.-M., Hardy M., Reddy U.R., Shi Q.-Y., Pleasure S.J., Lee V.M.-Y., Pleasure D.
     Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line.
[8] Tingley W.G., Roche K.W., Thompson A.K., Huganir R.L.
     Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain.
[9] Papadakis M., Hawkins L.M., Stephenson F.A.
     Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors.
[10] Gesell J.J.
     Thesis (1997), University of Pennsylvania, United States.

Order Confirmation: Sales order confirmations are sent out upon the receipt of all orders. Please contact GenWay if you do not receive a confirmation within 1 business day of submitting your order.

Precautions: GRIN1 antibody is for in vitro research use only. Not for use in diagnostics or therapeutic procedures.

Important Notes: During shipment, small volumes of GRIN1 antibody vial. For products with volumes of 200 µL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap. Actual concentration, volume and quantity will be printed on the vial's label. Please refer to the vials label for this information.

Copyright: This GenWay TDS is copyrighted. This datasheet is produced based partially on data from Swiss-Prot/TrEMBL and NCBI. To better serve our clients with everything we know about GRIN1 antibody, all related information, articles, resources about GRIN1 antibody are being stored on our online database. Let us know if you have questions regarding this product.

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