Recombinant Human β-NGF

GWB-BIG0E8

$0
Add to Cart

Description

Description: β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.

Synonyms: NGF-β

Sequence: SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

Biological Activity: determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Cross Reactivity: Chicken, Hamster, Mouse, Rat

Endotoxin: Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).

Source: E. Coli

Purity: 98%

Storage: -20°C

Protein Content: Verified by UV Spectroscopy and/or SDS-PAGE gel.

Additional Information

Name Recombinant Human β-NGF
Related Product Names NGF-β
Host E. Coli
Alias Symbols NGF-beta
Description of Target beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. beta-NGF is a potent neurotrophic factor that signals through its rec
Protein Name beta-nerve growth factor
Protein Accession Num NP_002497.2
Nucleotide Accession Nucleotide Accession NumNum NM_002506.2
Gene id 4803
Gene Fullname nerve growth factor
Species Reactivity Human, Chicken, Hamster, Mouse, Rat
Gene Symbol NGF
Swissprot ID P01138
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express NGF.
Intended Use Research Use Only
Purity 98% Verified by UV Spectroscopy and/or SDS-PAGE gel.
Storage -20°C
Sequence Length SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
rna_seq Find tissues and cell lines supported by RNA-seq analysis to express NGF.