IDH1 Antibody (GWB-A4GK5T)


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Name IDH1 Antibody (GWB-A4GK5T)
Availability In Stock
Gene Symbol IDH1
Gene Fullname isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Gene id 3417
Alias Symbols Cytosolic NADP-isocitrate dehydrogenase, IDCD, IDH, IDP, IDPC, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD
Swissprot ID O75874
Protein Name Isocitrate dehydrogenase [NADP] cytoplasmic
Description of Target Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Protein Accession Num NP_001269315.1
Nucleotide Accession Num NM_001282386.1
Clone C6
Host Mouse
Isotype IgG2a, kappa
Immunogen Recombinant IDH1 (Ala74~Ile333) expressed in E.coli
Product Format Liquid 0.01M PBS (pH 7.4) containing 0.05% Proclin300 and 50% glycerol
Purification Protein A & Protein G affinity chromatography
Concentration 1 mg/ml
Application WB, ICC, IHC
Clonality Monoclonal
Reconstitution and Storage Store at 4C. For long term storage, aliquot and store at -20C. Avoid freeze thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-A4GK5T
Species Reactivity Human