Mouse Anti HIV-1 p24 Antibody (GWB-488144) (Aviva Cat. No. OAPA00053)

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Please see item number OAPA00053 to view product details and for ordering information.


Aviva Cat. No.: OAPA00053


Additional Information

Name Mouse Anti HIV-1 p24 Antibody (GWB-488144)
Related Product Names HIV-1 p24, HIV-1 p24 Mouse, Mouse Anti HIV-1 p24HIV-1 p24
Gene Symbol HIV-1 p24
Alias Symbols HIV-1 p24 antibody, HIV-1 p24 Mouse antibody
Swissprot ID P04585
Protein Name Gag-Pol polyprotein
Description of Target Mouse Anti HIV-1 p24
Protein Accession Num NP_057849.4
Clone YDHIV1gp24
Host Mouse
Immunogen The immunogen for anti-HIV-1 p24 antibody: r.HIV-1p24.
Isotype Mouse IgG1.
Purity Ion exchange column.
Clonality Monoclonal
Format 1mg/ml in PBS (after reconstitution).
Reconstitution and Storage In lyophilized form, for long periods, store at 4C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20C.
Shipping Conditions: Antibody is shipped lyophilized at ambient temperature.
Datasheets/Manuals Printable datasheet for GWB-488144
Storage In lyophilized form, for long periods, store at 4C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20C.
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
Additional Information Titer: By direct ELISA (against recombinant gp24), 1:10,000 dilution will yield 0.4 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).
:: Product Type: Mouse antibody Monoclonal.
Reconstitution: Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4C.
:: Product Introduction: Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells.