NCBI Gene ID: 885 Preparation: Solid phase synthesis
Preservative Stabilisers: None present.
Reconstitution: Reconstitute with sterile distilled waterThis peptide is difficult to solubilise in water if the crystal is large. Solubility maybe helped by crushing the crystals prior to the addition of water. Function: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Subunit: Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity).
Subcellular Location: Secreted.
Ptm: The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Similarity: Belongs to the gastrin/cholecystokinin family. 1. Suzuki. T. et al (2008) Lack of relationship between blood glucose-lowering activity of colestimide and serum cholecystokinin (CCK) concentrations in patients with type 2 diabetes