Description
Vascular cell adhesion molecule 1(VCAM-1) is a cell surface glycoprotein adhesive for certain blood leukocytes and tumor cells, which is expressed by activated endothelium in a variety of pathologic conditions including atherosclerosis. Increased expression of VCAM1 is associated with a variety of chronic inflammatory conditions, making its expression and function a target for therapeutic intervention. Integrin alpha4beta1(VLA-4) and VCAM-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization. The VCAM1 gene is assigned to the 1p31-32 region of chromosome 1 based on the analysis of human-mouse hybrid cell lines and in situ hybridization. The standard product used in this kit is recombinant human VCAM-1, consisting of Phe25-Glu698 amino acid sequence of a single chain with the molecular mass of 74KDa. As a result of glycosylation, the molecular mass of 90-95KDa is revealed by SDS-PAGE.
Additional Information
| Name | Human VCAM-1 ELISA Kit (GWB-ZZD035) |
|---|---|
| Related Product Names | CD106| CD106 antigen| DKFZp779G2333| INCAM 100| INCAM-100| INCAM100| L1CAM| MGC99561| V CAM 1| V-CAM 1| Vascular cell adhesion molecule 1| Vascular cell adhesion protein 1| VCAM 1| VCAM-1| VCAM1| VCAM1_HUMAN |
| Short Description | Sandwich ELISA kit of Quantitative Detection for Human VCAM-1 |
| Immunogen | please inquire |
| Sample Type | This kit is used for quantitative detection of human VCAM-1 in cell culture supernates, serum and plasma(heparin, EDTA). |
| Swissprot ID | P19320 |
| Standard Range | 156pg/ml-10,000pg/ml. Test has a sensitivity of < 10 pg/ml |
| Specimen/Volumes | Refer to Manual |
| Concentration | Lot Specific |
| Application | ELISA |
| GI Number | 7412 |
| Stability | Four months at 4C and eight months at -20C. |
| Reactivity | Reactive to Human. There is no detectable cross-reactivity with other relevant proteins. |
| Kit Size | 1x96 well plate |
| Storage | Store at 4C for 6 months, at -20C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Datasheets/Manuals | Printable datasheet for GWB-ZZD035 |
| Intended Use | Research Use Only |