ERCC1

GWB-122D21

10-786-259106

0.01 mg
$394.20

Description

Amino SequenceFull length Activity: Not known

Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 61 kDa (Including GST). The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3\' of the DNA lesion while the ERCC1-XPF complex makes the 5\' incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells.

Additional Information

Name ERCC1
Availability Discontinued
Related Product Names RECOMBINANT HUMAN ERCC1 PROTEIN ERCC1
Swissprot ID P07992
Source Recombinant protein encoding human full length ERCC1 expressed i
Application ELISA, IA, WB
Format 100ul purified human ERCC1 Protein At 100ug/ ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol.
Storage Store vial at -20C to -80C. When stored at the recommended temperature, this protein is stable for 12 months.
Datasheets/Manuals Printable datasheet for GWB-122D21
Intended Use Research Use Only