EXOSC10 Protein (GWB-961C23) (Aviva Cat. No. OPPA01354)

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Please see item number GWB-961C23 to view product details and for ordering information.


Aviva Cat. No.: OPPA01354



EXOSC10 Human Recombinant produced in SF9 is a glycosylated, polypeptide chain.

Additional Information

Name EXOSC10 Protein (GWB-961C23)
Gene Symbol EXOSC10
Gene id 5394
Alias Symbols Exosome component 10, Polymyositis/scleroderma autoantigen 2, Autoantigen PM/Scl 2, Polymyositis/scleroderma autoantigen 100 kDa, PM/Scl-100, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, EXOSC10, PMSCL, PMSCL2, p2, p3, p4, RRP6,
Swissprot ID Q01780
Protein Name Exosome component 10
Description of Target EXOSC10 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis seen when other myositis and systemic sclerosis specific autoantibodies are present.
Protein Accession Num NP_001001998.1
Tag -6xHis tag
Product Format Liquid. 20mM HEPES, pH-7.5, 100mM NaCl, 0.01mM EDTA, 0.02% SDS
Physical Appearance: Sterile filtered clear solution
Molecular Weight 102 kDa
Purification Purified by proprietary chromatographic techniques
Concentration 0.8 mg/ml
Purity > 70% as determined by SDS-PAGE
Source Sf9 insect cells
Application Western-Blot with monoclonal anti-hexa-His-tag antibody & polymyositis patient sera.
Coating Concentration: 0.4-0.8 ug/ml (depending on the type of ELISA plate and coating buffer).
Suitable for biotinylation and iodination.
Reconstitution and Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-961C23
Lead Time Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Intended Use Research Use Only
Additional Information Immunological Functions:
1.) Binds IgG-type human auto-antibodies.
2.) Standard ELISA test (checker-board analysis of positive/negative sera panels).