Insulin Growth Factor Binding Protein-2 Mouse ELISA Kit (GWB-20ACA2)



1x96 well plate
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Product Name: Insulin Growth Factor Binding Protein-2 Mouse

Category: Growth Factors

Sample Type: Serum

Sensitivity: 0,04 ng/Ml

Description: Enzyme Immunoassay for Quantitative Determination of Mouse-Insulin-like Growth Factor Binding Protein-2.

# of Samples: 1X96 Assays

Intended Use: This IGFBP-2 Enzyme Immunoassay-Kit is suited for quantitative determination of IGFBP-2 in mouse serum for scientific purposes. Several rat sera (3 different ones) were used in this assay, but no IGFBP-2 could be proved.

Introduction: Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of Growth Hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of foetal tissue (11-13). The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6) (14). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism (15,16).

Technical Features +Applications: - Highly specific and sensitive assay for quantitative detection of IGFBP-2 in mouse serum
- Recombinant mouse IGFBP-2 as standard
- Uses antibodies against complete mouse IGFBP-2
- No sample extraction is required
- Detection limit: 0.04 ng/ml

Product Name: Insulin Growth Factor Binding Protein-2 Mouse

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Subunit: Binds IGF2 more than IGF1.

Subcellular Location: Secreted.

Similarity: Contains 1 IGFBP N-terminal domain.

Similarity: Contains 1 thyroglobulin type-1 domain.

Additional Information

Name Insulin Growth Factor Binding Protein-2 Mouse ELISA Kit (GWB-20ACA2)
Related Product Names Insulin Growth Factor Binding Protein-2 Mouse ELISA Kit; IGF-binding protein 2; IGFBP-2; IBP-2 BP2; IBP2Insulin Growth Factor Binding Protein-2 MouseIGFBP-2
Swissprot ID P18065
Molecular Weight 35138
Datasheets/Manuals Printable manual for GWB-20ACA2
Intended Use Research Use Only