Description
Similarity: Belongs to the lentiviruses env family.
Buffer: 100mM Sodium Phosphate, pH 6.0 containing 0.05% SDS
Inactivation: Not applicable
Function: The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.
Buffer: 100mM Sodium Phosphate, pH 6.0 containing 0.05% SDS
Inactivation: Not applicable
Function: The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.
Additional Information
| Name | HIV-1 env Ag conj. to gp36 (GWB-149775) |
|---|---|
| Related Product Names | HIV-1 env Ag conj. to gp36; Env polyprotein HIV-1 env Ag conj. to gp36env |
| Alias Symbols | Recombinant Human Immunodeficiency Virus Type 1 (HIV-1), envelope antigen conjugated to gp36 HIV-2 derived peptide |
| Swissprot ID | P03377 |
| Protein Name | Envelope glycoprotein gp160 |
| Host | E. coli/Synthetic |
| Product Format | Purified, Liquid |
| Specificity | HIV-1 Envelope Ag conj. to HIV-2 gp36 Peptide |
| Purity | >95% pure (HPLC-C4, and 10% PAGE). S-Sepharose, Ceramic Hydroxyapatite, S-300, G-25 and Dialysis. |
| Application | ELISA, WB |
| Application Data | Inactivation: Not applicable |
| Format | Purified, Liquid |
| Reconstitution and Storage | Short-term (up to 1 month) store at 2 to 8C. Long term store at -20C. |
| Storage | Short-term (up to 1 month) store at 2-8 C. Long term store at -20 C. |
| Datasheets/Manuals | Printable datasheet for GWB-149775 |
| Intended Use | Research Use Only |
| :: | Buffer: 100mM Sodium Phosphate, pH 6.0 containing 0.05% SDS Preservative: No |