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Human MMP-3 ELISA Kit

GWB-ZZD110

1x96 well plate
$539.10
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Description

Matrix metalloproteinase-3(MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase(MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition. The standard product used in this kit is recombinant human MMP-3, consisting of 460 amino acids with the molecular mass of 52KDa. The detected MMP-3 includes zymogen and active enzyme.

Additional Information

Name Human MMP-3 ELISA Kit
Related Product Names CHDS6|Matrix metalloproteinase 3|Matrix metalloproteinase 3 preproprotein|Matrix metalloproteinase-3|MGC126102|MGC126103|MGC126104|MMP 3|MMP-3|MMP3|MMP3_HUMAN|Progelatinase|Proteoglycanase|SL 1|SL-1|SL1|STMY|STMY1|STR1|Stromelisin 1|Stromelysin 1|Stromely
Short Description Sandwich ELISA kit of Quantitative Detection for Human MMP-3
Immunogen NSO, Y18-C477
Standard Range 156pg/ml-10,000pg/ml. Test has a sensitivity of < 10 pg/ml
Sample Type This kit is used for quantitative detection of human MMP-3 in cell culture supernates, serum and plasma(heparin).
Datasheets / Downloads GWB-ZZD110 Datasheet
Specimen/Volumes Refer to Manual
Swiss Prot Number P08254
Concentration Lot Specific
Applications ELISA
GI Number 4314
Stability Four months at 4C and eight months at -20C.
Reactivity Reactive to Human. There is cross-reactivates with MMP-10 approximately 2%, and no detectable cross-reactivity with other MMPs.
Kit Size 1x96 well plate
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Intended Use Research Use Only