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Human MMP-8 ELISA Kit


1x96 well plate
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Matrix metalloproteinase 8(MMP8) also called neutrophil collagenase. Neutrophil collagenase, a member of the family of matrix metalloproteinases, is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8, an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The human neutrophil collagenase(HNC) cDNA clone has been sequenced and shown to encode a 467-residue protein. Neutrophil collagenase has been found to possess 57% identity with the deduced protein sequence for fibroblast collagenase with 72% chemical similarity. Certain regions of the molecule, including the putative zinc-binding region, are highly conserved. When compared with the published sequence for fibroblast collagenase, neutrophil collagenase contains four additional sites for glycosylation. The standard product used in this kit is natural, isolating from human MMP-8. The detected MMP-8 includes zymogen and active enzyme.

Additional Information

Name Human MMP-8 ELISA Kit
Related Product Names BB138268|CLG 1|CLG1|Collagenase 1|Collagenase 1 neutrophil|HNC|Matrix metallopeptidase 8|Matrix metalloproteinase 8 (neutrophil collagenase)|Matrix metalloproteinase-8|MMP 8|MMP-8|Mmp8|MMP8_HUMAN|Neutrophil collagenase|PMNL CL|PMNL collagenase|PMNL-CL
Short Description Sandwich ELISA kit of Quantitative Detection for Human MMP-8
Sample Type This kit is used for quantitative detection of human MMP-8 in cell culture supernates, serum, plasma(heparin) and saliva.
Swissprot ID P22894
Immunogen NSO, F21-G467
Standard Range 156pg/ml-10,000pg/ml. Test has a sensitivity of < 10 pg/ml
Specimen/Volumes Refer to Manual
Concentration Lot Specific
Applications ELISA
GI Number 4317
Stability Four months at 4C and eight months at -20C.
Reactivity Reactive to Human. There is no detectable cross-reactivity with other relevant proteins.
Kit Size 1x96 well plate
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Datasheets/Manuals Printable datasheet for GWB-ZZD201
Intended Use Research Use Only