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Mouse MMP-3 ELISA Kit (GWB-ZZD111)


1x96 well plate
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Matrix metalloproteinase-3(MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase(MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition.

Additional Information

Name Mouse MMP-3 ELISA Kit (GWB-ZZD111)
Related Product Names CHDS6|Matrix metalloproteinase 3|Matrix metalloproteinase 3 preproprotein|Matrix metalloproteinase-3|MGC126102|MGC126103|MGC126104|MMP 3|MMP-3|MMP3|MMP3_HUMAN|Progelatinase|Proteoglycanase|SL 1|SL-1|SL1|STMY|STMY1|STR1|Stromelisin 1|Stromelysin 1|Stromely
Short Description Sandwich ELISA kit of Quantitative Detection for Mouse MMP-3
Immunogen NSO, Y18-C477
Sample Type This kit is used for quantitative detection of mouse MMP-3 in cell culture supernates, serum and plasma(heparin).
Swissprot ID P28862
Standard Range 156pg/ml-10,000pg/ml. Test has a sensitivity of < 10 pg/ml
Specimen/Volumes Refer to Manual
Concentration Lot Specific
Application ELISA
GI Number 17392
Stability Four months at 4C and eight months at -20C.
Reactivity Reactive to Mouse. There is cross-reactivates with MMP-10 approximately 2% and no detectable cross-reactivity with other MMPs.
Kit Size 1x96 well plate
Storage Store at 4C for 6 months, at -20C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Datasheets/Manuals Printable datasheet for GWB-ZZD111
Intended Use Research Use Only