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1x96 well plate
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Type IV collagenase, 72-kD, is officially designated matrix metalloproteinase-2(MMP2). It is also known as gelatinase, 72-kD. MMP-2 plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown.1 Matrix metalloproteinases(MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide(cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.2 The gene is localized to 16q21 using somatic cell hybrids and in situ hybridization.3 The standard product used in this kit is recombinant rat MMP-2, consisting of 662 amino acids with the molecular mass of 72KDa. The detected MMP-2 includes zymogen and active enzyme.

Additional Information

Name Rat MMP-2 ELISA Kit
Related Product Names 72 kDa gelatinase|72 kDa type IV collagenase|CLG 4|CLG 4A|CLG4|CLG4A|Collagenase type IV A|EC|Gelatinase A|Gelatinase alpha|Gelatinase neutrophil|Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|Matrix metall
Short Description Sandwich ELISA kit of Quantitative Detection for Rat MMP-2
Immunogen NSO, A30-C662
Standard Range 156pg/ml-10,000pg/ml. Test has a sensitivity of < 10 pg/ml
Sample Type This kit is used for quantitative detection of rat MMP-2 in cell culture supernates, serum and plasma(heparin).
Datasheets / Downloads GWB-ZZD134 Datasheet
Specimen/Volumes Refer to Manual
Swiss Prot Number P33436
Concentration Lot Specific
Applications ELISA
GI Number 81686
Stability Four months at 4C and eight months at -20C.
Reactivity Reactive to Rat. There is no detectable cross-reactivity with other relevant proteins.
Kit Size 1x96 well plate
Storage Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Intended Use Research Use Only