MMP-11, Antibody

GWB-15C287

20-203-420463

0.1 ml
$294.00

Description

Clone ID: EP1259Y

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen. Specificity: A synthetic peptide corresponding to residues near the C-terminus of human MMP-11 was used as an immunogen. Dilution: WB: 1:500
IHC: 1:100 - 250
ICC: 1:100 - 250. The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions (1). MMP-11 (stromelysin-3), a new member of the matrix metalloproteinase family, is expressed in tissues undergoing the active remodeling associated with embryonic development, wound healing and tumor invasion. But like all other members of the matrix metalloproteinase gene family, stromelysin-3 is synthesized as an inactive precursor that must be processed to its mature form in order to express enzymic activity (2). MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli (3). 1. Pei D, et al. Nature 375(6528):244-7, 1995.
2. Matrisian LM, et al. Trends Genet 6(4):121-5, 1990.
3. Nakopoulou L, et al. Nephrol Dial Transplant 22(1):109-17, 2007.
4. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name MMP-11, Antibody
Related Product Names MMP-11 Rabbit Monoclonal Antibody MMP11, STMY3, Stromelysin-3, Matrix metalloproteinase-11MMP-11
Swissprot ID P24347
Molecular Weight 58/45 (latent/ac
Source Rabbit
Applications WB, IHC, ICC
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-15C287
Intended Use Research Use Only