In observance of Thanksgiving, Genway Biotech office will be closed on Thursday and Friday, November 22-23, 2018

MMP-14, Antibody

GWB-171BC8

20-203-420568

0.1 ml
$294.00

Description

Clone ID: EP1264Y

Immunogen: A synthetic peptide corresponding to residues in human MMP-14 was used as an immunogen.

Specificity: A synthetic peptide corresponding to residues in human MMP-14 was used as an immunogen.

Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. 

Dilution: WB: 1:1000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
FC: 1:50
IP: 1:100.

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

1. Munger J, Bennett BD, Parikh A, et al, Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy ,Nature Biotechnology 26 (2008) 1179-1186
[Application: WB]
2. Clybouw C, Mchichi B EL , Hadji A, et al, TGFβ-mediated apoptosis of Burkitt’s lymphoma BL41cells is associated with the relocation of mitochondrial BimEL ,Oncogene 27 (2008) 3446-3456
[Application: WB, IP]
3. Fisher KE, Sacharidou A, Stratman AN, et al, MT1-MMP ,J Cell Sci 122 (2009) 4558-4569

1. Holmbeck K, et al. Cell 99(1):81-92, 1999.
2. Sato H, et al. Nature 370(6484):61-5, 1994.
3. Hotary KB, et al. Cell 114(1):33-45, 2003.
4. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name MMP-14, Antibody
Related Product Names MMP-14 Rabbit Monoclonal Antibody MMP14, Matrix metalloproteinase-14, MMP-X1MMP-14
Swissprot ID P50281
Molecular Weight 65 kDa
Source Rabbit
Applications WB, IHC, ICC, FC, IP
Clonality Monoclonal
Stability Stable for 12 months from date of receipt.
Reactivity Human, Mouse, Rat
Storage Store at -20C.
Datasheets/Manuals Printable datasheet for GWB-171BC8
Intended Use Research Use Only