MMP-2, Antibody

GWB-759502

20-783-71331

0.1 mg
$810.00

Description

Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 1. Soini. Y.

Additional Information

Name MMP-2, Antibody
Related Product Names MOUSE ANTI HUMAN MMP-2 MMP-2
Gene Symbol MMP2
Gene id 4313
Alias Symbols CLG4, MONA, CLG4A, TBE-1, MMP-II, MMP2
Swissprot ID P08253
Protein Name 72 kDa type IV collagenase
Description of Target MOUSE ANTI HUMAN MMP-2
Protein Accession Num NP_001121363.1
Clone CA4001
Host Mouse
Isotype IgG1
Immunogen The immunogen for anti-MMP2 antibody: synthetic peptide APSPIIKFPGDVAPKTDK corresponding to gelatinase
NCBI Acc Number NP_004521.1
Product Format Purified IgG - liquid
Specificity MMP-2
Applications IHC-F, WB
Application Info Immunohistology - Frozen:    1/100 - 1/1000
GI Number 11342666
Clonality Monoclonal
Format Purified
Stability 18 months from date of despatch.
Reconstitution and Storage Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Storage Store at +4Cor at -20Cif preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recom
Datasheets/Manuals Printable datasheet for GWB-759502
Intended Use Research Use Only
Key Reference 1. Soini, Y. et al. (1994) 72kD and 92kD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization. J. Histochem. Cytochem. 42: 945-951.
2. Autio Harmainen, H. et al. (1993) Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors. Lab. Invest. 69: 312-321.
Additional Information Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the P3X63Ag8.653 myeloma cell line.
Histology Positive Control Tissue: Trophoblast
:: Preparation: Purified IgG prepared by affinity chromatography
Preservative Stabilisers: 0.09% - Sodium Azide
:: Approx Protein Conc: IgG concentration 1.0mg/ml
Buffer Solutions: 0.1M glycine HCl, 1M TRIS HCl, pH 7-8