Description
Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. 1. Soini. Y.
Additional Information
| Name | MMP-2, Antibody |
|---|---|
| Related Product Names | MOUSE ANTI HUMAN MMP-2 MMP-2 |
| Gene Symbol | MMP2 |
| Gene id | 4313 |
| Alias Symbols | CLG4, MONA, CLG4A, TBE-1, MMP-II, MMP2 |
| Swissprot ID | P08253 |
| Protein Name | 72 kDa type IV collagenase |
| Description of Target | MOUSE ANTI HUMAN MMP-2 |
| Protein Accession Num | NP_001121363.1 |
| Clone | CA4001 |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | The immunogen for anti-MMP2 antibody: synthetic peptide APSPIIKFPGDVAPKTDK corresponding to gelatinase |
| NCBI Acc Number | NP_004521.1 |
| Product Format | Purified IgG - liquid |
| Specificity | MMP-2 |
| Applications | IHC-F, WB |
| Application Info | Immunohistology - Frozen: 1/100 - 1/1000 |
| GI Number | 11342666 |
| Clonality | Monoclonal |
| Format | Purified |
| Stability | 18 months from date of despatch. |
| Reconstitution and Storage | Store at +4oC or at -20oC if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Reactivity | Human |
| Storage | Store at +4Cor at -20Cif preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recom |
| Datasheets/Manuals | Printable datasheet for GWB-759502 |
| Intended Use | Research Use Only |
| Key Reference | 1. Soini, Y. et al. (1994) 72kD and 92kD type IV collagenase, type IV collagen, and laminin mRNAs in breast cancer: a study by in situ hybridization. J. Histochem. Cytochem. 42: 945-951. 2. Autio Harmainen, H. et al. (1993) Expression of 72 kilodalton type IV collagenase (gelatinase A) in benign and malignant ovarian tumors. Lab. Invest. 69: 312-321. |
| Additional Information | Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of the P3X63Ag8.653 myeloma cell line. Histology Positive Control Tissue: Trophoblast |
| :: | Preparation: Purified IgG prepared by affinity chromatography Preservative Stabilisers: 0.09% - Sodium Azide |
| :: | Approx Protein Conc: IgG concentration 1.0mg/ml Buffer Solutions: 0.1M glycine HCl, 1M TRIS HCl, pH 7-8 |