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MMP-2, Antibody

GWB-233973

20-203-421267

0.1 ml
$294.00

Description

Clone ID: EPR1184

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human MMP-2 was used as an immunogen. Specificity: A synthetic peptide corresponding to residues near the C-terminus of human MMP-2 was used as an immunogen. Dilution: WB: 1:1,000 - 5,000
FC: 1:70. The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread. MMP2, also known as Gelatinase A, is a type IV collagenase that specifically cleaves type IV collagen, the major structural component of basement membranes. The metastatic potential of tumor cells has been found to correlate with the activity of this enzyme (1). MMP2 is regulated differently from other MMPs, suggesting that it may play a unique role in cell-matrix interactions, including cell invasion. The conversion from the 72 kDa progelatinase A to the active 62 kDa species may be a key event in the acquisition of invasive potential (2). 1. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name MMP-2, Antibody
Related Product Names MMP-2 Rabbit Monoclonal Antibody MMP-2
Swissprot ID P08253
Molecular Weight (Pro MMP-2)/59-6
Source Rabbit
Applications WB, FC
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-233973
Intended Use Research Use Only