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MMP-8, Antibody

GWB-24977E

20-203-420694

0.1 ml
$294.00

Description

Clone ID: EP1252Y

Immunogen: A synthetic peptide corresponding to residues in human MMP-8 was used as an immunogen. Specificity: A synthetic peptide corresponding to residues in human MMP-8 was used as an immunogen. Dilution: WB: 1:2000
IHC: 1:100 - 250
ICC: 1: 100 - 250
FC: 1:20
IP: 1:50. The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumor invasion and tumour spread (1). Matrix Metalloporteinase 8 (MMP-8, Collagenase-2, Neutrophil Collagenase) functions mainly to degrade fibrillar type I, II, and III collagens, serpins, and aggrecan. MMP-8 degrades by cleaving at one specific on the fibrillar collagens with higher cleave activity on type I compared to type III collagens. MMP-8 is expressed in neutrophils, chondrocytes, and gingival fibroblasts (2). 1. Murray GI, et al. J Pathol, 185(3):256-61
2. Van Lin P, Libert C, Cytokine Growth Factor Rev. 17(4):217-223, 2006.
3. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name MMP-8, Antibody
Related Product Names MMP-8 Rabbit Monoclonal Antibody MMP8, CLG1, Neutrophil collagenase, PMNL collagenaseMMP-8
Swissprot ID P22894
Molecular Weight 72 kDa
Source Rabbit
Applications WB, IHC, ICC
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-24977E
Intended Use Research Use Only