Description
Summary: This protein is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq].
Additional Information
| Name | RECOMBINANT HUMAN TNF ALPHA (GWB-10B349) |
|---|---|
| Availability | Discontinued |
| Related Product Names | RECOMBINANT HUMAN TNF ALPHA |
| Gene Symbol | TNF |
| Gene Family | TNFSF |
| Gene id | 7124 |
| Alias Symbols | DIF, TNFA, TNFSF2, TNF-alpha, TNF |
| Swissprot ID | P01375 |
| Protein Name | Tumor necrosis factor |
| Description of Target | RECOMBINANT HUMAN TNF ALPHA |
| Protein Accession Num | NP_000585.2 |
| Homology | Human |
| NCBI Acc Number | NP_000585.2 |
| Product Format | Purified recombinant protein - lyophilised |
| Molecular Weight | 17.5 kD (157 amino acids) |
| Purity | SDS PAGE: >97% |
| Application | ELISA |
| GI Number | 25952111 |
| Format | Purified recombinant protein - lyophilised |
| Reconstitution and Storage | Reconstitution: Reconstitute in sterile DI water to 0.1 mg/ml for storage and further dilution. Storage: Prior to reconstitution store at +4oC. After reconstitution store at -20oC. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. |
| Reactivity | Human |
| Sequence Length | 233 |
| Storage | Store with a desiccant at -20C. |
| Datasheets/Manuals | Printable datasheet for GWB-10B349 |
| Species Reactivity | Human |
| Intended Use | Research Use Only |
| Additional Information | Activity: Approximately 2x10(e)7 units/mg. This was determined by cytolysis of murine cells in the presence of actinomycin-D. |
| :: | Endotoxin Level: < 0.1 ng/ ug |
| :: | Label Protein Molar Ratio: Expressed in E. coli Preservative: None present |