Description
Summary: This protein is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq].
Additional Information
Name | RECOMBINANT HUMAN TNF ALPHA (GWB-10B349) |
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Related Product Names | RECOMBINANT HUMAN TNF ALPHA |
Gene Symbol | TNF |
Gene Family | TNFSF |
Gene id | 7124 |
Alias Symbols | DIF, TNFA, TNFSF2, TNF-alpha, TNF |
Swissprot ID | P01375 |
Protein Name | Tumor necrosis factor |
Description of Target | RECOMBINANT HUMAN TNF ALPHA |
Protein Accession Num | NP_000585.2 |
Homology | Human |
NCBI Acc Number | NP_000585.2 |
Product Format | Purified recombinant protein - lyophilised |
Molecular Weight | 17.5 kD (157 amino acids) |
Purity | SDS PAGE: >97% |
Application | ELISA |
GI Number | 25952111 |
Format | Purified recombinant protein - lyophilised |
Species Reactivity | Human |
Reconstitution and Storage | Reconstitution: Reconstitute in sterile DI water to 0.1 mg/ml for storage and further dilution. Storage: Prior to reconstitution store at +4oC. After reconstitution store at -20oC. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. |
Reactivity | Human |
Sequence Length | 233 |
Datasheets/Manuals | Printable datasheet for GWB-10B349 |
Storage | Store with a desiccant at -20C. |
Lead Time | Domestic: within 2-3 weeks delivery | International: 2-3 weeks |
Intended Use | Research Use Only |
Additional Information | Activity: Approximately 2x10(e)7 units/mg. This was determined by cytolysis of murine cells in the presence of actinomycin-D. |
:: | Endotoxin Level: < 0.1 ng/ ug |
:: | Label Protein Molar Ratio: Expressed in E. coli Preservative: None present |