SYNTHETIC Human KALLIDIN II Protein (GWB-18A216)

GWB-18A216

10-783-79488

5 mg
$160.00

Description

Similarity: Contains 3 cystatin domains.

Function: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Additional Information

Name SYNTHETIC Human KALLIDIN II Protein (GWB-18A216)
Availability Discontinued
Related Product Names SYNTHETIC HUMAN KALLIDIN II BDK; KNGKALLIDIN IIKNG1
Gene Symbol KNG1
Gene Family ENDOLIG
Gene id 3827
Alias Symbols BDK, KNG, KNG1
Swissprot ID P01042
Protein Name Kininogen-1
Description of Target SYNTHETIC HUMAN KALLIDIN II
Protein Accession Num NP_000884.1
Peptide Sequence KRPPGFSPFR
Homology Human
Product Format Purified synthetic peptide - lyophilised
Molecular Weight 1188.2 Da_x000D_
Purity HPLC: >99%_x000D_
Application ELISA
Format Purified
Stability 18 months from date of despatch.
Reconstitution and Storage Reconstitution: Reconstitute with 1.0ml distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Aviva Systems Biology recommend that the vial is gently mixed after reconstitution.
Reactivity Human
Storage Prior to reconstitution store at +4 degree C.
After reconstitution store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the prot
Datasheets/Manuals Printable datasheet for GWB-18A216
Species Reactivity Human
Intended Use Research Use Only
Additional Information Approx Protein Conc: 5.0 mg/ml
Buffer solution: Acetate salt
:: Label Protein Molar Ratio: Solid phase synthesis
Preservative: None present