Description
Description: This product is a 15 amino acid peptide corresponding to amino acid residues 1300 - 1314 located at the C-terminus of the Clostridium tetani tetanus toxin heavy chain according to entres protein accession number CAA28033.
Similarity: Belongs to the peptidase M27 family [view classification]. 1. Eisel. U.
Function: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Similarity: Belongs to the peptidase M27 family [view classification]. 1. Eisel. U.
Function: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.
Additional Information
| Name | SYNTHETIC TETANUS TOXIN PEPTIDE (C-TERMINAL) Protein (GWB-118D68) |
|---|---|
| Related Product Names | SYNTHETIC TETANUS TOXIN PEPTIDE (C-TERMINAL) TETANUS TOXINtetX |
| Description of Target | SYNTHETIC TETANUS TOXIN PEPTIDE (C-TERMINAL) |
| Gene Symbol | tetX |
| Gene id | 1061100 |
| Swissprot ID | P04958 |
| Protein Name | Tetanus toxin |
| Protein Accession Num | NP_783831.1 |
| Peptide Sequence | CDWYFVPTDEGWTND |
| Product Format | Purified synthetic peptide - liquid |
| Application | ELISA |
| Format | Purified synthetic peptide - liquid |
| Stability | 6 months from date of reconstitution. |
| Reconstitution and Storage | Store at -20C only. Storage in frost-free freezers is not recommended. Following reconstitution this product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Storage | Store at -20 degree C only. Storage in frost-free freezers is not recommended. Following reconstitution this product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a prec |
| Datasheets/Manuals | Printable datasheet for GWB-118D68 |
| Lead Time | Domestic: within 2-3 weeks delivery | International: 2-3 weeks |
| Intended Use | Research Use Only |
| Key Reference | 1. Eisel, U. et al. (1986) Tetanus toxin: primary structure, expression in E. coli, and homology with botulinum toxins. EMBO J. 5: 2495-2502. |
| Additional Information | Approx Protein Conc: 1 mg/ml |
| :: | Label Protein Molar Ratio: Solid phase synthesis Preservative: None present |