Description
Bone morphogenetic protein-2(BMP-2, BMP 2A) belongs to the transforming growth factor beta(TGF-beta) superfamily. It is thought to be involved in cartilage and bone formation during embryogenesis, but may have additional functions in morphogenesis as implied by its expression in various organs and embryonic tissues of mice.1 BMP-2 has been identified as a candidate mediator of retinoid activity. BMP-2 protein induces medulloblastoma cell apoptosis, whereas the BMP-2 antagonist noggin blocks both retinoid and BMP-2-induced apoptosis. BMP-2 also induces p38 mitogen-activated protein kinase(MAPK), which is necessary for BMP-2 and retinoid-induced apoptosis.2 Bone morphogenic proteins(BMPs) are known to promote osteogenesis, and clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture-healing and spinal fusion.3 The standard product used in this kit is recombinant human BMP-2, constituting dimer by two chains of 114 amino acids with the molecular mass of 26KDa.
Additional Information
| Name | Human BMP-2 ELISA Kit (GWB-ZZD138) |
|---|---|
| Related Product Names | BDA2|BMP-2|BMP-2A|Bmp2|BMP2_HUMAN|BMP2A|Bone morphogenetic protein 2|Bone morphogenetic protein 2A |
| Short Description | Sandwich ELISA kit of Quantitative Detection for Human BMP-2 |
| Sample Type | This kit is used for quantitative detection of human BMP-2 in bone tissue, cell culture supernates and serum. |
| Swissprot ID | C8C060 |
| Immunogen | CHO, Q283-R396 |
| Standard Range | 62.5pg/ml-4000pg/ml. Test has a sensitivity of < 2 pg/ml |
| Specimen/Volumes | Refer to Manual |
| Concentration | Lot Specific |
| Application | ELISA |
| GI Number | 650 |
| Stability | Four months at 4C and eight months at -20C. |
| Reactivity | Reactive to Human. There is no detectable cross-reactivity with other relevant proteins. |
| Kit Size | 1x96 well plate |
| Datasheets/Manuals | Printable datasheet for GWB-ZZD138 |
| Storage | Store at 4C for 6 months, at -20C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.) |
| Intended Use | Research Use Only |