Sequence: MEGVHRKPSL LAHPGPLVKS EETVILQCWS DVRFQHFLLH REGKFKDTLH LIGEHHDGIS KANFSIGPMM QDLAGTYRCY GSVTHSPYQL SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS RSSYDMYHLS REGEAHERRF SAGPKVNGTF QADFPLGPAT HGGTYRCFGS FRDSPYEWSN SSDPLLVSVT GN Concentration: 1mg/ml An inhibitory Killer Cell Ig-like Receptor (KIR, previously called p58 KIR, cl-6, NKAT2 or KIR-K7), which recognizes class I MHC molecules (HLA-Cw1, -Cw3, -Cw7, and Cw8). The protein coding region of the extracellular domain of KIR2DL3 (amino acid 1-202) was cloned into an E. coli expression vector. The extracellular domain of KIR2DL3 protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer.
Function: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular Location: Cell membrane; Single-pass type I membrane protein.
Similarity: Belongs to the immunoglobulin superfamily.
Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. 1. Steffens, U. et al. (1998) Tissue Antigens 51, 398-413.
1. Wagtmann, N. R., et al. (1995) Immunity 2, 439-449.
1. Colonna, M. et al. (1995) Science 268, 405-408.
1. Kim, J. et al. (1997) J. Immunol. 159, 3875-3882