Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized pHGF in sterile 18M-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions. Hepatocyte Growth Factor porcine is extracted from pig liver.
The HGF is purified by proprietary chromatographic techniques.
Hepatocyte Growth Factor (HGF) is a multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. HGF synergizes with Interleukin-3and GM-CSFto stimulate colony formation of hematopoietic progenitor cells in vitro and may, therefore, also modulate hematopoiesis.
Function: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.
Subunit: Dimer of an alpha chain and a beta chain linked by a disulfide bond.
Similarity: Belongs to the peptidase S1 family. Plasminogen subfamily [view classification].
Similarity: Contains 4 kringle domains.
Similarity: Contains 1 PAN domain.
Similarity: Contains 1 peptidase S1 domain [view classification].