PKAkt1/PKBa Protein (GWB-86FD71)

GWB-86FD71

10-663-46016

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Description

Similarity: Contains 1 protein kinase domain.

Function: General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis, partly by playing a role in both insulin-induced phosphorylation of 4E-BP1 and in insulin-induced activation of p70 S6 kinase. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Additional Information

Name PKAkt1/PKBa Protein (GWB-86FD71)
Availability In Stock
Related Product Names RAC-alpha serine/threonine-protein kinase, EC 2.7.11.1, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, AKT, RAC, PRKBA, MGC99656, RAC-ALPHA.; EC 2.7.11.1; RAC-PK-alpha; Protein kinase B; PKB; C-AKT PKB; RACPKAkt1/PKBa HumanAKT1
Gene Symbol PKAkt1/PKBa
Gene id 207
Alias Symbols RAC-alpha serine/threonine-protein kinase, EC 2.7.11.1, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, AKT, RAC, PRKBA, MGC99656, RAC-ALPHA, PKAkt1/PKBa Human, Protein Kinase Akt1/PKB alpha, Active enzyme Human Recombinant
Swissprot ID P31749
Protein Name RAC-alpha serine/threonine-protein kinase
Description of Target Recombinant Human Protein Kinase Akt1/PKB alpha Active Enzyme
Protein Accession Num NP_001014431.1
Host Sf9 Insect Cells
NCBI Acc Number NP_001014431.1
Product Format PKAkt1 1.9mg/ml, in 50mM NaCl, 1mM DTT, 25mM beta glycerophosphate, 50% glycerol, pH 8.5. Physical appearance: Sterile Filtered clear solution.
Purity Greater than 90% as determined by SDS-PAGE.
Format PKAkt1 1.9mg/ml, in 50mM NaCl, 1mM DTT, 25mM beta glycerophosphate, 50% glycerol, pH 8.5.
Reconstitution and Storage Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Avoid multiple freeze-thaw cycles. Unit Definition20. 000 Units/mg (1 Unit = 1 pmol/min transferred to synthetic peptide RPRAATF at 30Celsius). No protease activity detectable.
Storage Store at 4 C if entire vial will be used within 2-4 weeks. Store, frozen at -20 C for longer periods of time. Avoid multiple freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for GWB-86FD71
Intended Use Research Use Only
:: Product Introduction: Akt1, also known as "Akt" or protein kinaseB (PKB) is an important molecule in mammaliancellular signaling.In humans, there are three genes in the "Akt family": Akt1, Akt2, and Akt3. These enzymesare members of the serine/threonine-specific protein kinasefamily (EC2.7.11.1).Akt1 is involved in cellular survival pathways, by inhibiting apoptoticprocesses. Akt1 is also able to induce protein synthesispathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogenein the transforming retrovirus, AKT8.
Product Description: Recombinant Human Protein Kinase B is a glycosylated polypeptide having a molecular mass of 59.1 kDa. Recombinant Protein Kinase B is purified by proprietary chromatographic techniques.