Calcium/Calmodulin Kinase IV (CaMKIV) Antibody (GWB-1555A8)



0.1 ml


Clone ID: EP2565AY

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human CaMKIV was used as an immunogen. Specificity: A synthetic peptide corresponding to residues near the C-terminus of human CaMKIV was used as an immunogen. Dilution: WB: 1:100,000 - 500,000
IHC: 1:250 - 500
FC: 1:60
IP: 1:60. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a multifunctional protein kinase expressed abundantly in the central nervous system. Because changes in intracellular Ca(2+) concentrations affect progression through the mitotic cell cycle, enhanced expression of CaMKIV has been reported in small cell lung carcinoma and hepatocellular carcinoma (1). Multifunctional Ca2+/calmodulin kinase IV is enriched in neurons and T lymphocytes. The kinase is absent from primary human B lymphocytes but is expressed in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cell lines, suggesting that expression of the kinase can be upregulated by an EBV gene products. In view of the key role played by LMP1 in B-lymphocyte immortalization by EBV, findings implicate Ca2+/calmodulin kinase IV as a potential mediator of B-lymphocyte growth transformation (2). Ca2+/calmodulin kinase IV can suppress the MT-regulating activity of Op18 by phosphorylation on Ser-16. These results show that Op18 phosphorylation by Ca2+/calmodulin kinase IV may couple alterations of MT dynamics in response to external signals that involve Ca2+ (3). 1. Takai N, et al. Cancer Lett, 183(2) 185-93, 2002.
2. Mosialos G, et al. J Virol 68(3): 1697-705, 1994
3. Melander Gradin H, et al. Mol Cell Biol 17(6): 3459-67, 1997.
4. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name Calcium/Calmodulin Kinase IV (CaMKIV) Antibody (GWB-1555A8)
Related Product Names Calcium/Calmodulin Kinase IV (CaMKIV) Rabbit Monoclonal Antibody CAMK4, Calcium/calmodulin-dependent protein kinase type IV, CAM kinase-GRCalcium/Calmodulin Kinase IV (CaMKIV)
Swissprot ID Q16566
Molecular Weight 60 kDa
Source Rabbit
Application WB, IHC, FC, IP
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-1555A8
Intended Use Research Use Only