CD36, Antibody

GWB-3B384A

20-321-175191

0.1 mg
$405.90
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Description

Clone: FA6-152 Applications: The monoclonal antibody FA6-152 can be used for immuno precipitation. immuno assays as coating. flow cytometry. Western blotting and immunohistology on frozen sections. Furthermore the monoclonal antibody FA6-152 is useful for neutralization of the biological activity of CD36. Monoclonal antibody FA6-152 reacts with CD36 (88-kDa). a cell surface class B scavenger receptor. Recently. CD36 has been identified as a protein that is required for TLR2 recognition of di-acylated bacterial lipopeptides and lipoteichoic acid4. CD36 is a heavily N-glycosylated transmembrane protein of 90 kDa with two short intracellular domains and a large extracellular domain. CD36 expression is primarily controlled by the transcription heterodimer PPARg-RXR (peroxisome proliferator-activated receptor-g-retinoid-X-receptor). CD36 is preferentially found within lipid rafts. which facilitates its association with receptors. signalling and adaptor molecules. CD36 is expressed on platelets. mature monocytes and macrophages. microvascular endothelial cells. mammary endothelial cells. during stages of erythroid cell development and on some macrophage derived dendritic cells. CD36 has been implicated in many biological processes including angiogenesis. phagocytosis. inflammation. and lipid and glucose metabolism. CD36 is associated with Src-family kinases and with the integrins a3b1 and a6b1. It is a receptor and transporter of oxidized lipids and long chain fatty acids. CD36 has been shown to function as phagocytic receptor for apoptotic cells. Several in vivo models support the role of the thrombospondin / CD36 system in angiogenesis and tumor growth. An important role for CD36 has been found in Malaria as major receptor for P. falciparum-infected red blood cells. Many different ligands have been reported to interact with CD36. suggesting that CD36 could recognize a structure-based domain rather than specific contact residues. Monoclonal antibody FA6-152 blocks the biological activity of CD36 by blocking collagen/thrombospondin binding.

Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.

Subcellular Location: Membrane; Multi-pass membrane protein.

Ptm: N-glycosylated and O-glycosylated with a ratio of 2:1.

Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection.

Disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.

Similarity: Belongs to the CD36 family. [1] Armesilla,A.L. and Vega,M.A., et al.
Structural organization of the gene for human CD36 glycoprotein
[2] Vega,M.A., et al.
Direct Submission
[3] Oquendo P., Hundt E., Lawler J., Seed B.
CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.
[4] Sugimoto Y., Tsuruo T.
Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
[5] Taylor K.T., Tang Y., Sobieski D.A., Lipsky R.H.
Characterization of two alternatively spliced 5\'-untranslated exons of the human CD36 gene in different cell types.
[6] Wyler B., Daviet L., Bortkiewicz H., Bordet J.C., McGregor J.L.
Cloning of the cDNA encoding human platelet CD36: comparison to PCR amplified fragments of monocyte, endothelial and HEL cells.
[7] Armesilla A.L., Vega M.A.
Structural organization of the gene for human CD36 glycoprotein.
[8] Rieder M.J., Armel T.Z., Carrington D.P., Chung M.-W., Lee K.L., Ozuna M., Poel C.L., Toth E.J., Yi Q., Nickerson D.A., et al.
SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu).
[9] Tandon N.N., Lipsky R.H., Burgess W.H., Jamieson G.A.
Isolation and characterization of platelet glycoprotein IV (CD36).
[10] Gelhaus A., Scheding A., Browne E., Burchard G.D., Horstmann R.D.
Variability of the CD36 gene in West Africa.

Additional Information

Name CD36, Antibody
Related Product Names MONOCLONAL ANTIBODY TO HUMAN CD36; Platelet glycoprotein IV; GPIV; Glycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; CD36 antigen; PAS IV; PAS-4 protein; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor GP3
Swissprot ID P16671
NCBI Acc Number CAA83662.1
Molecular Weight 53053
Source Mouse IgG1
GI Number 525233
Clonality Monoclonal
Format 1 ml (100 ug/ml) 0.2 um filtered antibody solution in PBS containing 0.1% bovine serum albumin.
Stability Stable for 1 year
Reactivity Human
Sequence Length 472
Storage Product should be stored at 4 degree C
Datasheets/Manuals Printable datasheet for GWB-3B384A
Intended Use Research Use Only