RABBIT ANTI HUMAN IKK ALPHA (C2) (aa699-715) Antibody

GWB-562832

18-783-313935

0.05 mg
$190.00

Description

Function: Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. Ref.17

Additional Information

Name RABBIT ANTI HUMAN IKK ALPHA (C2) (aa699-715) Antibody
Availability Discontinued
Related Product Names IKKA, TCF16RABBIT ANTI HUMAN IKK ALPHA (C2) (aa699-715)CHUK
Gene Symbol CHUK
Gene id 1147
Alias Symbols IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, CHUK
Swissprot ID O15111
Protein Name Inhibitor of nuclear factor kappa-B kinase subunit alpha
Description of Target RABBIT ANTI HUMAN IKK ALPHA (C2) (aa699-715)
Protein Accession Num NP_001269.3
Host Rabbit
Isotype Polyclonal IgG
Immunogen The immunogen for anti-CHUK antibody: synthetic peptide corresponding to amino acids 699-715 of human IKK Alpha
Homology Human
Product Format Purified IgG - liquid
Specificity IKK
Application WB
Application Data Application #1: Western blot analysis of IKK alpha in HeLa whole cell lysate
Clonality Polyclonal Antibody
Format Purified IgG - liquid
Stability 18 months from date of despatch.
Reconstitution and Storage Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Reactivity Human
Application Info Western Blotting:    1/500
Storage Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product cont
Datasheets/Manuals Printable datasheet for GWB-562832
Species Reactivity Human
Intended Use Research Use Only
Key Reference 1. Woronicz, J.D. et al. (1997) I Kappa B kinase-beta: NF-kappa B activation and complex formation with I Kappa B kinase-alpha and NIK. Science 278: 866-9.
:: Preservative Stabilisers: 0.02% - Sodium Azide
Antiserum Preparation: Antisera to human IKK Alpha (C2) were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
:: Approx Protein Conc: IgG concentration 0.5 mg/ml
Buffer Solutions: Phosphate buffered saline