IRS-1 Antibody (GWB-79D4E2)

GWB-79D4E2

20-203-420312

0.1 ml
$294.00

Description

Clone ID: EP263Y

Immunogen: A synthetic peptide corresponding to residues near the C-terminus of human IRS-1was used as immunogen. Specificity: A synthetic peptide corresponding to residues near the C-terminus of human IRS-1was used as immunogen. Dilution: WB: 1:1,000
IHC: 1:50-100
ICC: 1:250-500
IP: 1:50. Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5) 1. Sun XJ, Rothenberg P, Kahn CR, et al. 1991 Nature. 352:73
2. White MF. 1997 Diabetologia. 40:S2
3. Virkamaki, A., Ueki, K., and Kahn, C. R. (1999) J. Clin. Investig. 103, 931
4. Araki E, Lipes MA, Patti ME, et al. 1994 Nature. 372:186
5. Abe H, Yamada N, Kamata K, et al. 1998 J Clin Invest. 101:1784
6. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name IRS-1 Antibody (GWB-79D4E2)
Related Product Names IRS-1 Rabbit Monoclonal Antibody IRS1, Insulin receptor substrate 1IRS-1
Swissprot ID P35568
Molecular Weight 170 kDa
Source Rabbit
Application WB, IHC, ICC, IP
Clonality Monoclonal
Reactivity Human
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-79D4E2
Intended Use Research Use Only