Phospho-Jak2 (pY1007/1008) Antibody (GWB-7062C6)

GWB-7062C6

20-203-420123

0.1 ml
$326.00

Description

Clone ID: E132

Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1007 and Tyr1008 of human JAK2 was used as immunogen. The antibody only detects JAK2 phosphorylated on Tyrosine 1007 and 1008. Specificity: A synthetic phospho-peptide corresponding to residues surrounding Tyr1007 and Tyr1008 of human JAK2 was used as immunogen. The antibody only detects JAK2 phosphorylated on Tyrosine 1007 and 1008. Dilution: WB: 1:5,000-10,000
IHC: 1:50-100
ICC: 1:50-100
IP: 1:50. Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the signal transducers and activators of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, and phosphorylation at these residues is needed for Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a form of pre-B acute myeloid leukemia (4). 1. Leonard, W.J. and J.J. O
2. O\'Shea, J.J., et al. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J Clin Immunol. 17: 431
3. Gauzzi, M.C., et al. Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. J. Biol. Chem. 271: 20494
4. Peeters, P., et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90: 2535
5. Manufactured under U.S. Patents, No. 5,675,063 and 7,429,487

Additional Information

Name Phospho-Jak2 (pY1007/1008) Antibody (GWB-7062C6)
Availability Discontinued
Related Product Names Phospho-Jak2 (pY1007/1008) Rabbit Monoclonal Antibody JAK2, Tyrosine-protein kinase JAK2, Janus kinase 2Phospho-Jak2 (pY1007/1008)
Swissprot ID O60674
Molecular Weight 130 kDa
Source Rabbit
Application WB, IHC, ICC, IP
Clonality Monoclonal
Reactivity Human, Mouse, Rat
Storage Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Datasheets/Manuals Printable datasheet for GWB-7062C6
Intended Use Research Use Only