DUSP22 (MKPX) , Active (GWB-710CAD)

GWB-710CAD

10-782-55029

$0.00

Description

Application Note: Kinase assay Recombinant full length human DUSP22 was expressed in E.coli cells using a N-terminal GST tag.

Function: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase /c-Jun N-terminal kinase (SAPK/JNK) (By similarity).

Catalytic Activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Catalytic Activity: A phosphoprotein + H2O = a protein + phosphate.

Subcellular Location: Cytoplasm (By similarity). Nucleus (By similarity).

Tissue Specificity: Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas.

Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Similarity: Contains 1 tyrosine-protein phosphatase domain. [1] Alonso,A., Narisawa,S., Bogetz,J., Tautz,L., Hadzic,R., Huynh,H., Williams,S., Gjorloff-Wingren,A., Bremer,M.C., Holsinger,L.J.,, et al.
VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX
[2] Alonso,A., Narisawa,S., Bogetz,J., Tautz,L., Hadzic,R., Huynh,H., Williams,S., Gjorloff-Wingren,A., Bremer,M.C., Holsinger,L.J.,, et al.
VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX
[3] Chen,A.J., Zhou,G., Juan,T., Colicos,S.M., Cannon,J.P., Cabriera-Hansen,M., Meyer,C.F., Jurecic,R., Copeland,N.G.,, et al.
The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway
[4] Alonso,A., Merlo,J.J., Na,S., Kholod,N., Jaroszewski,L., Kharitonenkov,A., Williams,S., Godzik,A., Posada,J.D. and, et al.
Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR)
[5] Shen,Y., Luche,R., Wei,B., Gordon,M.L., Diltz,C.D. and Tonks,N.K., et al.
Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1
[6] Shen Y., Luche R., Wei B., Gordon M.L., Diltz C.D., Tonks N.K.
Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1.
[7] Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., et al.
Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndromes patient.
[8] Mao Y., Xie Y., Cheng H.
Cloning and characterization of human LMW-DSP2 gene.
[9] Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., et al.
The DNA sequence and analysis of human chromosome 6.
[10] Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.

Additional Information

Name DUSP22 (MKPX) , Active (GWB-710CAD)
Availability Discontinued
Related Product Names EC 3.1.3.48; EC 3.1.3.16; JNK-stimulatory phosphatase-1; JSP-1; Mitogen-activated protein kinase phosphatase x; LMW-DSP2 JSP1; MKPXDual specificity protein phosphatase 22DUSP22
Swissprot ID Q9NRW4
NCBI Acc Number NP_064570.1
Molecular Weight 0.5
Source E Coli
GI Number 9910432
Stability 1 year at -20 degree C.
Sequence Length 184
Storage Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
Datasheets/Manuals Printable datasheet for GWB-710CAD
Intended Use Research Use Only